{"id":31613,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-glp-1t-sobre-el-metabolismo-de-la-glucosa-en-el-higado\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"efectos-del-glp-1t-sobre-el-metabolismo-de-la-glucosa-en-el-higado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efectos-del-glp-1t-sobre-el-metabolismo-de-la-glucosa-en-el-higado\/","title":{"rendered":"Efectos del glp-1t sobre el metabolismo de la glucosa en el higado."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Morales Sanchez <\/strong><\/h2>\n<p>Los peptidos glp-1 estan implicados en la regulacion del metabolismo de la glucosa en el higado.  en hepatocitos aislados de rata, el glp-1t a dosis fisiologicas, y tambien el glp-1, estimulan, como la insulina, la sintesis de glucogeno, resultando ser incluso mas potentes que esta.  el efecto glucogenico de ambos glps es dependiente de la dosis, y tambien de la concentracion de glucosa. Ademas, es claramente antagonico al del glucagon, y aditivo al de la insulina, cuando las dosis utilizadas son submaximas.  en el hepatocito aislado de la rata el efecto glucogenico del glp-1t va acompa\u00f1ado de una estimulacion de la actividad glucogeno-sintasa; ademas, el peptido estimula la oxidacion de la glucosa, y la liberacion de lactato.  la accion de los peptidos glp-1 amidados, en el higado, parece estar mediada por la activacion de una fosfodiesterasa que cataboliza el ampc, ya que se observa una disminucion del contenido de ampc, solo en ausencia de ibmx.  el glp-1t no tiene efecto sobre la actividad adenilato ciclasa, indicando que el receptor del glp-1t en el higado es funcionalmente distinto del pancreatico.  el glp-1t en el higado parece tener a un inositolfosfoglicano como segundo mensajero de su accion, al igual que la insulina, aunque no se descarte la existencia de otros mediadores.  nuestros resultados indican, por tanto, que los peptidos glp-1 ejercen efectos insulinomimeticos en el higado, y que, como la insulina, pueden jugar un papel importante en el aclaramiento y la homeostasis de la glucosa.  estas acciones directas del glp-1t, aparte de sus efectos insulinotropicos, a\u00f1aden un beneficio a su propuesto uso como tratamiento de la diabetes mellitus no insulino-dependiente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del glp-1t sobre el metabolismo de la glucosa en el higado.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del glp-1t sobre el metabolismo de la glucosa en el higado. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Morales Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Valverde Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Moreno Mu\u00f1oz Fco. Jose <\/li>\n<li>Jos\u00e9 Enrique Campillo \u00e1lvarez (vocal)<\/li>\n<li>Enrique Bl\u00e1zquez Fern\u00e1ndez (vocal)<\/li>\n<li>Mar\u00eda  Luisa Villanueva-pe\u00f1acarrillo Molina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Morales Sanchez Los peptidos glp-1 estan implicados en la regulacion del metabolismo de la glucosa en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,258,17],"tags":[3180,5536,1743,87963,87961,87962],"class_list":["post-31613","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-hormonas","category-quimica","tag-enrique-blazquez-fernandez","tag-isabel-valverde-alonso","tag-jose-enrique-campillo-alvarez","tag-maria-luisa-villanueva-penacarrillo-molina","tag-monica-morales-sanchez","tag-moreno-munoz-fco-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/31613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=31613"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/31613\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=31613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=31613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=31613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}