{"id":31618,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":""},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"analisis-molecular-del-genoma-del-virus-c-de-la-hepatitis-vch-en-suero-higado-y-celulas-mononucleares-de-sangre-periferica-de-pacientes-portadores-cronicos-del-vch-y-estudio-de-sus-implicaciones-pa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-molecular-del-genoma-del-virus-c-de-la-hepatitis-vch-en-suero-higado-y-celulas-mononucleares-de-sangre-periferica-de-pacientes-portadores-cronicos-del-vch-y-estudio-de-sus-implicaciones-pa\/","title":{"rendered":"Analisis molecular del genoma del virus c de la hepatitis (vch) en suero, higado y celulas mononucleares de sangre periferica de pacientes portadores cronicos del vch y estudio de sus implicaciones patogenicas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Navas Martin <\/strong><\/h2>\n<p>Este estudio ha permitido avanzar en el conocimiento de algunos aspectos importantes de la biopatolog\u00eda de la infeccion por virus c de la hepatitis (vch), que todavia no son suficientemente conocidos, estudiandose: 1) la presencia de las cadenas genomica y antigenomica del rna-vch en suero, en higado y celulas mononucleares de sangre periferica (cmsp) de pacientes con hepatitis cronica c y de portadores asintomaticos; 2) las cantidades de virus detectables en suero, higado y cmsp, las relaciones que hay entre ellas y con otros factores como el genotipo del vch; 3) la importancia de la metodolog\u00eda empleada en el analisis de genotipos y subtipos del vch y el desarrollo de un metodo de tipaje especifico, demostrado por analisis de secuenciacion; y por ultimo, 4) demostrandose la existencia de una compartimentalizacion de secuencias dentro de un mismo individuo infectado, compartimentalizacion que se manifiesta a dos niveles: genotipo (con un linfotropismo muy marcado para el genotipo 1, y sobre todo el subtipo 1b), y en el espectro de secuencias mutantes que se genera en pacientes infectados por un unico genotipo, lo que puede estar relacionado con la alta persistencia de la infeccion por vch y su capacidad para escapar de la respuesta del sistema inmune del huesped y a los tratamientos con los agentes habituales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis molecular del genoma del virus c de la hepatitis (vch) en suero, higado y celulas mononucleares de sangre periferica de pacientes portadores cronicos del vch y estudio de sus implicaciones patogenicas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis molecular del genoma del virus c de la hepatitis (vch) en suero, higado y celulas mononucleares de sangre periferica de pacientes portadores cronicos del vch y estudio de sus implicaciones patogenicas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Navas Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Carre\u00f1o Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Arturo Fernandez-cruz <\/li>\n<li>Mercedes Ruiz Moreno (vocal)<\/li>\n<li>Cecilio Jim\u00e9nez Mart\u00edn (vocal)<\/li>\n<li>Maximo Sandin Dominguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Navas Martin Este estudio ha permitido avanzar en el conocimiento de algunos aspectos importantes de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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