{"id":31675,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-en-el-metabolismo-de-la-metionina-y-sensibilidad-al-estres-oxidativo-en-celulas-cho-que-sobreexpresan-el-gen-de-la-metionina-adenosiltransferasa-hepatica\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"alteraciones-en-el-metabolismo-de-la-metionina-y-sensibilidad-al-estres-oxidativo-en-celulas-cho-que-sobreexpresan-el-gen-de-la-metionina-adenosiltransferasa-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/alteraciones-en-el-metabolismo-de-la-metionina-y-sensibilidad-al-estres-oxidativo-en-celulas-cho-que-sobreexpresan-el-gen-de-la-metionina-adenosiltransferasa-hepatica\/","title":{"rendered":"Alteraciones en el metabolismo de la metionina y sensibilidad al estres oxidativo en celulas cho que sobreexpresan el gen de la metionina adenosiltransferasa hepatica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Estrella Sanchez Gongora <\/strong><\/h2>\n<p>Los cambios que se originan en el metabolismo de la metionina son, en muchos casos, debidos a deficiencias en la metionina adenosiltransferasa (mat), enzima que cataliza la sintesis de s-adenosilmetionina a partir de atp y metionina. Para estudiar la repercusion de un incremento de la actividad mat en el ciclode la metionina, se transfectaron establemente celulas chinese hamster ovary (cho) con el cdna de la mat de higado de rata. Se obtuvieron clones celulares con un aumento considerable de la actividad mat, acompa\u00f1ado de una elevacion de los niveles citosolicos de sam y una reduccion en los de atp y nad. Se incremento tambien la relacion sam\/sah y se potenciaron las reacciones de metilacion y transaminopropilacion. Por el contrario, ni las caracteristicas morfologicas ni el crecimiento celular, se vieron modificados. Las celulas cho que sobreexpresan la mat; fueron sometidas a distintas agresiones de tipo fisico y quimico, comprobandose que se incrementaba su sensibilidad frente a agentes como la radiacion ultravioleta (uv c) y oxidantes como el peroxido de hidrogeno.  por otra parte, se observo que la interaccion de radicales libres, hidroxilo, con la cys-121 (cisteina-121) de la mat hepatica parece ser determinante para la reduccion de la actividad enzimatica. Se propone que la mat hepatica podria actuar como un sensor del estres oxidativo, cuya actividad se encuentra modulada por el estado redox celular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones en el metabolismo de la metionina y sensibilidad al estres oxidativo en celulas cho que sobreexpresan el gen de la metionina adenosiltransferasa hepatica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones en el metabolismo de la metionina y sensibilidad al estres oxidativo en celulas cho que sobreexpresan el gen de la metionina adenosiltransferasa hepatica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Estrella Sanchez Gongora <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Mato De La Paz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Emilio Feliu Albi\u00f1ana <\/li>\n<li>Juan Vi\u00f1a Ribes (vocal)<\/li>\n<li>Jes\u00fas M. Prieto Valtue\u00f1a (vocal)<\/li>\n<li>Lisardo Bosc\u00e1 Gomar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Estrella Sanchez Gongora Los cambios que se originan en el metabolismo de la metionina son, en muchos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,160,35,9399,17],"tags":[88073,15059,14571,14572,11637,5664],"class_list":["post-31675","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-bioquimica","category-ciencias-de-la-vida","category-cultivo-celular","category-quimica","tag-estrella-sanchez-gongora","tag-jesus-m-prieto-valtuena","tag-jose-maria-mato-de-la-paz","tag-juan-emilio-feliu-albinana","tag-juan-vina-ribes","tag-lisardo-bosca-gomar"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/31675","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=31675"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/31675\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=31675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=31675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=31675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}