{"id":31714,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/induccion-en-la-rata-de-un-modelo-de-esclerosis-del-tubo-seminifero-por-la-accion-toxica-del-cloruro-de-cadmio-estudio-inmunohistoquimico-y-estereologico\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"induccion-en-la-rata-de-un-modelo-de-esclerosis-del-tubo-seminifero-por-la-accion-toxica-del-cloruro-de-cadmio-estudio-inmunohistoquimico-y-estereologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/induccion-en-la-rata-de-un-modelo-de-esclerosis-del-tubo-seminifero-por-la-accion-toxica-del-cloruro-de-cadmio-estudio-inmunohistoquimico-y-estereologico\/","title":{"rendered":"Induccion en la rata de un modelo de esclerosis del tubo seminifero por la accion toxica del cloruro de cadmio. estudio inmunohistoquimico y estereologico ."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Torres Moreta M. Dolores <\/strong><\/h2>\n<p>En el presente trabajo se estudia, desde el punto de vista inmunocitoqu\u00edmico y cuantitativo, el comportamiento de la t\u00fanica propia del t\u00fabulo semin\u00edfero de la rata, tras el tratamiento con cloruro de cadmio. Se utilizaron 54 ratas wistar macho. 36 fueron tratadas con una dosis subcut\u00e1nea de 0,03 mmol\/kg de cloruro de cadmio y 18 fueron utilizadas como controles recibiendo soluci\u00f3n salina est\u00e9ril carente de cadmio. El estudio inmunohistoqu\u00faimico incluy\u00f3bromodeoxiuridina, ant\u00edgeno nuclear de proliferaci\u00f3n celular (pcna), vimentina, fibronectina, alfa actina, laminina, col\u00e1geno iv, testosterona y factor transformador del crecimiento beta1. Se realiz\u00f3 un an\u00e1lisis semicuantitativo de las inmunotinciones y un estudio cuantitativo determinando:  volumen testicular, volumen ocupado por el tubo semin\u00edfero, di\u00e1metro tubular medio y longitud tubular, inmunorrectividad para la brdu y cuantificaci\u00f3n estereol\u00f3gica del n\u00famero de c\u00e9lulas mioides. Tras la necrosis inicial masiva celular de los tubos semin\u00edferos y del intersticio, tiene lugar precozmente un incremento de la proliferaci\u00f3n que se inicia en la albug\u00ednea y, posteriormente, se extiende a zonas testiculares m\u00e1s internas. El endotelio de los vasos de la albug\u00ednea y subalbug\u00edneos presentan menor sensibilidad a la lesi\u00f3n t\u00f3xica del cloruro de cadmio, por lo que la albug\u00ednea se encuentra mejor preservada. Previamente a la instauraci\u00f3n de la esclerosis tubular aumenta la proliferaci\u00f3n de c\u00e9lulas mioides, que puede ser modulada por el factor de crecimiento beta1. La reestructuraci\u00f3n de la pared del tubo semin\u00edfero a trav\u00e9s de procesos cicatriciales, se produce en los tubos semin\u00edferos que no experimentan necrosis total del epitelio y conduce a la esclerosis tubular. En localizaciones alejadas de la albug\u00ednea, la necrosis del epitelio es masiva y los tubos se calcifican, sin evolucionar a la esclerosis. En el transcurso de la esclerosis tubular producida por<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Induccion en la rata de un modelo de esclerosis del tubo seminifero por la accion toxica del cloruro de cadmio. estudio inmunohistoquimico y estereologico .<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Induccion en la rata de un modelo de esclerosis del tubo seminifero por la accion toxica del cloruro de cadmio. estudio inmunohistoquimico y estereologico . <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Torres Moreta M. Dolores <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Santamar\u00eda Solis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ricardo Paniagua G\u00f3mez-\u00e1lvarez <\/li>\n<li>Pilar Mart\u00ednez Onsurbe (vocal)<\/li>\n<li>Godofredo Dieguez Castrillo (vocal)<\/li>\n<li> Ramirez Garcia Jos\u00e9 Ramon (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Torres Moreta M. Dolores En el presente trabajo se estudia, desde el punto de vista inmunocitoqu\u00edmico y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,35,9,3153,52,156],"tags":[5795,14596,47822,59404,14274,88135],"class_list":["post-31714","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-ciencias-de-la-vida","category-ciencias-medicas","category-histologia-humana","category-histopatologia","category-patologia","tag-godofredo-dieguez-castrillo","tag-luis-santamaria-solis","tag-pilar-Martinez-onsurbe","tag-ramirez-garcia-jose-ramon","tag-ricardo-paniagua-gomez-alvarez","tag-torres-moreta-m-dolores"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/31714","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=31714"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/31714\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=31714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=31714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=31714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}