{"id":3197,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/biological-studies-with-growth-factors-in-multiple-myeloma-efect-of-il-6-and-alfa-interferon-on-the-proliferation-of-multiple-myeloma-in-vitro-and-the-clinical-efficacy-of-alfa-interferon-in-vivo\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"biological-studies-with-growth-factors-in-multiple-myeloma-efect-of-il-6-and-alfa-interferon-on-the-proliferation-of-multiple-myeloma-in-vitro-and-the-clinical-efficacy-of-alfa-interferon-in-vivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/biological-studies-with-growth-factors-in-multiple-myeloma-efect-of-il-6-and-alfa-interferon-on-the-proliferation-of-multiple-myeloma-in-vitro-and-the-clinical-efficacy-of-alfa-interferon-in-vivo\/","title":{"rendered":"Biological studies with growth factors in multiple myeloma; efect of il-6 and alfa-interferon on the proliferation of multiple myeloma in vitro and the clinical efficacy of alfa-interferon in vivo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Montes Borinaga <\/strong><\/h2>\n<p>El mieloma multiple (m.M.) Es una enfermedad maligna caracterizada por la proliferacion monoclonal de celulas plasmaticas. Se ha estudiado el efecto de la quimioterapia y factores de crecimiento en la clonogenicidad del m.M.  mediante un ensayo clonogenico, se han estudiado los efectos del tratamiento con quimioterapia en altas dosis sobre la clonogenicidad in vitro de las celulas mielomatosas y mieloides obtenidas de aspirados medulares de pacientes con m.M.  tambien se han estudiado los efectos de la il-6 sobre la clonogenicidad de las lineas celulares de mieloma y de il-6 y alfa-interferon in vitro sobre celulas obtenidas de aspirados medulares de pacientes con m.M.  los resultados muestran: baja clonogenicidad de la fraccion mieloide y mielomatosa en el m.M., La il-6 no es un factor de crecimiento para m.M., Aunque es un co-factor para la mielopoyesis; los pacientes tratados con melfalan en altas dosis muestran una disminucion de los precursores mieloides y mielomatosos in vitro; el alfa-interferon tiene un efecto citostatico in vitro y constituye un tratamiento efectivo en el mantenimiento de la remision obtenida con quimioterapia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Biological studies with growth factors in multiple myeloma; efect of il-6 and alfa-interferon on the proliferation of multiple myeloma in vitro and the clinical efficacy of alfa-interferon in vivo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Biological studies with growth factors in multiple myeloma; efect of il-6 and alfa-interferon on the proliferation of multiple myeloma in vitro and the clinical efficacy of alfa-interferon in vivo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Montes Borinaga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Barbara Millar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Felipe De Miguel <\/li>\n<li>Jennifer Treleaven (vocal)<\/li>\n<li>Martin Gore (vocal)<\/li>\n<li>Alfonso Sanchez Ibarrola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Montes Borinaga El mieloma multiple (m.M.) Es una enfermedad maligna caracterizada por la proliferacion monoclonal de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,195,347,12909,156],"tags":[13420,13415,13416,13417,13418,13419],"class_list":["post-3197","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-hemopatologia","category-oncologia-clinica","category-pais-vasco-euskal-herriko-unibertsitatea","category-patologia","tag-alfonso-sanchez-ibarrola","tag-ana-montes-borinaga","tag-barbara-millar","tag-felipe-de-miguel","tag-jennifer-treleaven","tag-martin-gore"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/3197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=3197"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/3197\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=3197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=3197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=3197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}