{"id":32019,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-y-factores-predictivos-de-la-respuesta-de-la-hepatitis-cronica-por-virus-c-con-interferon-alfa\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"tratamiento-y-factores-predictivos-de-la-respuesta-de-la-hepatitis-cronica-por-virus-c-con-interferon-alfa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/tratamiento-y-factores-predictivos-de-la-respuesta-de-la-hepatitis-cronica-por-virus-c-con-interferon-alfa\/","title":{"rendered":"Tratamiento y factores predictivos de la respuesta de la hepatitis cronica por virus c con interferon alfa."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Aguiar Bautista Jos\u00e9 Alberto <\/strong><\/h2>\n<p>Objetivos: 1.-Conocer la respuesta al interferon (ifn) alfa en los pacientes en pacientes con hepatitis cronica por virus c (vhc) de nuestro medio (gran canaria).  2.-Identificar los factores predictivos de respuesta.  3.-Comprobar la pauta terapeutica mas eficaz.  material y metodos: en la unidad monografica de hepatitis cronica viral (gran canaria) se estudiaron de forma prospectiva 176 pacientes con hepatitis cronica por vhc tratados con ifn alfa (3-6 mui 3 veces por semana), que incluian dos grupos segun la duracion del tratamiento (grupo i correspondia a 6 meses y grupo ii a 12 meses).  en todos ellos se elaboro un protocolo detallado consistente en datos epidemiologicos, clinicos, analiticos e histologicos, y se hizo un seguimiento de 6 meses tras la suspension del ifn.  resultados: el 44.9% de los pacientes del grupo ii y el 9.3% del grupo i normalizaron las transaminasas al finalizar el tratamiento. El 21.5%de los pacientes del grupo ii tuvo una respuesta completa sostenida, hecho que no ocurrio en ningun caso del grupo i (p&lt;0.001). Al comparar ambos grupos, se observo que los sujetos del grupo i presentaban una mayor edad (p&lt;0.05) y una mayor severidad en las lesiones hepaticas en la histolog\u00eda (p&lt;0.001). Mas de la mitad de los pacientes presentaron efectos secundarios. En el analisis univariable, los siguientes factores se relacionaron de forma significativa con una respuesta completa: la edad inferior a 50 a\u00f1os, unas cifras plasmaticas bajas de fosfatasa alcalina, ggt y ferritina, y elevadas de c3, la ausencia de hepatitis cronica activa severa y cirrosis, y la normalizacion de la alt durante los primeros meses de tratamiento. En el analisis multivarible, los factores con valor predictivo de respuesta completa al ifn fueron la normalizacion de la alt a los 3 meses de iniciado el tratamiento, el menor grado de da\u00f1o hepatico en la histolog\u00eda y unas cifras bajas de fosfatasa alcalina. Los factores predictiv<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento y factores predictivos de la respuesta de la hepatitis cronica por virus c con interferon alfa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento y factores predictivos de la respuesta de la hepatitis cronica por virus c con interferon alfa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Aguiar Bautista Jos\u00e9 Alberto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodriguez San Roman Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro Betancor Le\u00f3n <\/li>\n<li>Carlos Casanova Trujillo (vocal)<\/li>\n<li>Zoilo Gonz\u00e1lez Lama (vocal)<\/li>\n<li>Fermin Rodriguez Moreno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aguiar Bautista Jos\u00e9 Alberto Objetivos: 1.-Conocer la respuesta al interferon (ifn) alfa en los pacientes en pacientes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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