{"id":32284,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-preclinica-de-nuevas-moleculas-con-actividad-ansiolitica-y-afinidad-por-receptores-serotoninergicos\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"evaluacion-preclinica-de-nuevas-moleculas-con-actividad-ansiolitica-y-afinidad-por-receptores-serotoninergicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/evaluacion-preclinica-de-nuevas-moleculas-con-actividad-ansiolitica-y-afinidad-por-receptores-serotoninergicos\/","title":{"rendered":"Evaluacion preclinica de nuevas moleculas con actividad ansiolitica y afinidad por receptores serotoninergicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Bonilla Jos\u00e9 Miguel <\/strong><\/h2>\n<p>En la tesis doctoral se estudian nuevas moleculas de estructura mixta imido-piperacina valorandose, en primer lugar, su afinidad por receptores 5-htla y posteriormente en test farmacologicos que estudian la actividad agonistica 5-ht1a como son el test de la hipotermia, la influencia que sobre la hipotermia inducida por las nuevas sustancias tiene la adiccion del agonista serotoninergico 80hdpat y el test de retraccion del labio inferior de la rata (rli). Finalmente se estudio su perfil ansiolitico en el test de los dos compartimentos.  las conclusiones fueron las siguientes: (1) desde el punto de vista metodologico, los estudios realizados con 80hdpat permiten afirmar que la evaluacion de la temperatura rectal en el raton y el rli constituyen dos metodos \u00abin vivo\u00bb de utilidad para el estudio de agentes que actuan a traves de mecanismos 5-ht1a. (2) el test del doble compartimento constituye un metodo util de deteccion del perfil de actividad ansiolitica de agentes benzodiacepinicos y de los que actuan a traves de mecanismos no gabergicos. (3) el farmaco b-20292 muestra un claro perfil ansiolitico dosis-dependiente superior al del diazepan en nuestras condiciones experimentales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluacion preclinica de nuevas moleculas con actividad ansiolitica y afinidad por receptores serotoninergicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluacion preclinica de nuevas moleculas con actividad ansiolitica y afinidad por receptores serotoninergicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Bonilla Jos\u00e9 Miguel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Cecilio \u00e1lamo Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Eduardo Cuenca Fernandez <\/li>\n<li>Eduardo Arilla Ferreiro (vocal)<\/li>\n<li>Francisco Javier Galiana Martinez (vocal)<\/li>\n<li>Francisco Lopez Mu\u00f1oz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Bonilla Jos\u00e9 Miguel En la tesis doctoral se estudian nuevas moleculas de estructura mixta imido-piperacina valorandose, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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