{"id":32323,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":""},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-comparativo-de-los-efectos-de-diversos-inhibidores-de-eca-sobre-la-actividad-nerviosa-simpatica-sistema-renina-angiotensina-y-niveles-de-6-ceto-preostaglandina-f1-a-e-insulin-like-growth-fact","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-comparativo-de-los-efectos-de-diversos-inhibidores-de-eca-sobre-la-actividad-nerviosa-simpatica-sistema-renina-angiotensina-y-niveles-de-6-ceto-preostaglandina-f1-a-e-insulin-like-growth-fact\/","title":{"rendered":"Estudio comparativo de los efectos de diversos inhibidores de eca sobre la actividad nerviosa simpatica, sistema renina-angiotensina y niveles de 6-ceto-preostaglandina f1-a e insulin-like growth factor-1 (igf-1) en pacientes con hipertension arterial esencial."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rodriguez Garcia Jos\u00e9 Luis <\/strong><\/h2>\n<p>A fin de estudiar si existen diferencias en los mecanismos de accion de diferentes inhibidores de la enzima conversora de angiotensina (eca) pertenecientes a los tres grupos farmacologicos (sulfidrilo, hidroxilo, fosforilo), se ha realizado un ensayo clinico abierto aleatorizado mediante el estudio de 44 pacientes con hipertension arterial esencial ligera-moderada de edad entre 35 y 70 a\u00f1os, a quienes se dividieron en 4 grupos segun el farmaco empleado (enalapril, fosinopril, captopril, ramipril). Dentro del estudio se evaluaron: 1.  respuesta de la presion arterial (pas, pad, pam) y de la frecuencia cardiaca (fc) al test presor del frio (tpf); 2. Niveles de neropinefrina basal y en respuesta al tpf; 3. Efectos del tratamiento con un inhibidor de eca, estudiando los siguientes parametros: a. Eficacia clinica; b. Modulacion de la respuesta presora y cronotropa en el test presor del frio; c. Niveles de norepinefrina plasmatica en el tpf; d. Excrecion urinaria de norepinefrina y dopamina; e. Actividad del sistema renina-angiotensina-aldosterona circulante; f. Niveles de 6-ceto-pgf1 alfa (metabolito estable de prostaciclina) en orina; g. Concentraciones plasmaticas de insulin-like growth factor-1 (igf-1).  a los sujetos con hta se les realizo el test presor del frio en dos ocasiones: en el primer estudio (basal), todos los pacientes tuvieron un periodo de lavado (ausencia de toma de medicacion) de 10 dias. A continuacion se comenzo el tratamiento con un inhibidor de eca, realizandose un segundo estudio al cabo de 8 semanas, momento en el que se habia logrado un control adecuado de la presion arterial o bien el paciente se encontraba con la dosis maxima establecida del farmaco (captopril 150 mg\/dia, enalapril 40 mg\/dia, ramipril 10 mg\/dia, fosinopril 40 mg\/dia). Los estudios se realizaron en situacion de balance sodico de una dieta libre en ingesta de sal. Se recogio orina de 24 horas el dia previo a la realizacion de cada test, tom<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio comparativo de los efectos de diversos inhibidores de eca sobre la actividad nerviosa simpatica, sistema renina-angiotensina y niveles de 6-ceto-preostaglandina f1-a e insulin-like growth factor-1 (igf-1) en pacientes con hipertension arterial esencial.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio comparativo de los efectos de diversos inhibidores de eca sobre la actividad nerviosa simpatica, sistema renina-angiotensina y niveles de 6-ceto-preostaglandina f1-a e insulin-like growth factor-1 (igf-1) en pacientes con hipertension arterial esencial. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rodriguez Garcia Jos\u00e9 Luis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Garcia Robles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Manzano Espinosa <\/li>\n<li> Ruilope Urioste Luis Miguel (vocal)<\/li>\n<li>Vicente Lahera Julia (vocal)<\/li>\n<li>Cristina Alvarez Escola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodriguez Garcia Jos\u00e9 Luis A fin de estudiar si existen diferencias en los mecanismos de accion de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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