{"id":32375,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-los-factores-reguladores-del-interferon-irf-1-e-irf-2-en-pacientes-con-hepatitis-cronica-c\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"expresion-de-los-factores-reguladores-del-interferon-irf-1-e-irf-2-en-pacientes-con-hepatitis-cronica-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-de-los-factores-reguladores-del-interferon-irf-1-e-irf-2-en-pacientes-con-hepatitis-cronica-c\/","title":{"rendered":"Expresion de los factores reguladores del interferon, irf-1 e irf-2, en pacientes con hepatitis cronica c."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alexander Alberdi Sola <\/strong><\/h2>\n<p>Los factores reguladores del interferon, irf-1 e irf-2, son proteinas nucleares que se unen a los genes del interferon (ifn) y a los genes inducibles por ifn, con un efecto transcripcional positivo y negativo, respectivamente.  el objetivo es determinar los niveles de rnam de irf-1 e irf-2 en pacientes con hepatitis cronica c (hc-c) y observar estos niveles tras estimulacion con virus sendai o ifn-alfa. Se incluyeron 20 controles sanos (c) y 53 pacientes con hc-c. De ellos, 38 eran virus de la hepatitis c (vhc)+ en suero y en celulas mononucleares de sangre periferica (cmsp) por la tecnica rt-pcr. Los 15 restantes eran pacientes con respuesta sostenida (vhc-) tras 12 meses de tratamiento con ifn y con un seguimiento mayor de 1 a\u00f1o. Los niveles de rnam de irfs fueron determinados en cmsp no cultivadas, asi como en cmsp cultivadas con virus sendai o ifn-alfa. Posteriormente, se realizo rt-pcr semicuantitativa a partir del rna extraido de esas celulas. Se amplifico el gen de la beta-actina como control interno.  los resultados indican que el nivel de rnam de irf-1 es significativamente mayor en pacientes vhc+ que en controles sanos (0.076+-0.007 vs. 0.045+-0.005; p&lt;0.02).  los pacientes vhc- muestran un nivel intermedio (0.059+-0.008; ns), sin diferencias significativas frente a los otros dos grupos. Tras estimulacion con virus sendai o ifn-alfa, los niveles de rnam de irf-1 aumentaron hasta alcanzar valores similares en todos los grupos. No encontramos diferencias significativas en el nivel de rnam de irf-2 tanto antes (c: 0.8+-0.077, vhc+:  0.828+-0.066, vhc-: 0.771+-0.098; ns) como despues de la estimulacion con virus sendai o ifn-alfa.  conclusion: la infeccion por vhc se asocia a un aumento en la expresion del irf-1, lo que sugiere que el vhc persiste en la celula pese a la activacion del sistema interferonico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion de los factores reguladores del interferon, irf-1 e irf-2, en pacientes con hepatitis cronica c.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion de los factores reguladores del interferon, irf-1 e irf-2, en pacientes con hepatitis cronica c. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alexander Alberdi Sola <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pilar Civeira Murillo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Morell Oca\u00f1a <\/li>\n<li>Oscar Beloqui Ruiz (vocal)<\/li>\n<li>Jos\u00e9 Antonio Solis  Herruzo (vocal)<\/li>\n<li>Juan  Francisco Medina Cabrera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alexander Alberdi Sola Los factores reguladores del interferon, irf-1 e irf-2, son proteinas nucleares que se unen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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