{"id":32390,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-nefrotoxicidad-por-ifosfamida-en-pacientes-pediatricos-con-tumores-solidos-malignos\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-de-la-nefrotoxicidad-por-ifosfamida-en-pacientes-pediatricos-con-tumores-solidos-malignos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-nefrotoxicidad-por-ifosfamida-en-pacientes-pediatricos-con-tumores-solidos-malignos\/","title":{"rendered":"Estudio de la nefrotoxicidad por ifosfamida en pacientes pediatricos con tumores solidos malignos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pascual Barona Zamora <\/strong><\/h2>\n<p>Se ha estudiado la nefrotoxicidad aguda y evolucion de la misma causada por la ifosfamida en 20 pacientes pediatricos con tumores solidos malignos. Hemos utilizado en metodo del aclaramiento de litio para valorar el manejo renal del sodio y agua, y para comparar sus resultados los de pruebas estandar utilizadas por otros autores.  la ifosfamida ha causado de forma aguda un incremento significativo del aclaramiento y escrecion fraccional de litio, reabsorcion distal de sodio y agua, fostaturia, excrecion de beta2-microglobulina y n-acetilglucosaminidasa, asi como un descenso significativo de la reabsorcion proximal de sodio y agua.  otros parametros no han presentado modificaciones significativas pero si alteraciones puntuales incluso con frecuencia considerable.  se ha correlacionado positivamente con la dosis de ifosfamida: aclaramiento y excrecion fraccional de litio, reabsorcion distal de sodio y agua, diuresis, y excrecion renal de beta 2-microglobulina y n-acetilglucosaminidasa.  se han correlacionado negativamente la reabsorcion proximal fraccional de sodio, reabsorcion proximal de agua, fosfatemia y umbral renal de fosfato.  concluimos que la ifosfamida puede producir netrotoxicidad aguda, incluyendo cambios en el manejo renal del sodio y agua, predominantemente en el tubulo proximal y que la toxicidad renal puede progresar en relacion con la dosis acumulada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la nefrotoxicidad por ifosfamida en pacientes pediatricos con tumores solidos malignos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la nefrotoxicidad por ifosfamida en pacientes pediatricos con tumores solidos malignos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pascual Barona Zamora <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Sierrasesumaga Ariznabarreta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Garcia Fuentes <\/li>\n<li>Andr\u00e9s Purroy Unanua (vocal)<\/li>\n<li>Juan Rodriguez Soriano (vocal)<\/li>\n<li>Consuelo Modesto Caballero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pascual Barona Zamora Se ha estudiado la nefrotoxicidad aguda y evolucion de la misma causada por la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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