{"id":32462,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":""},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"induccion-de-anticuerpos-frente-al-antigeno-de-superficie-del-virus-de-la-hepatitis-b-en-animales-no-respondedores-a-dicho-antigeno-implicaciones-en-la-prevencion-y-en-el-tratamiento-de-la-hepatitis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/induccion-de-anticuerpos-frente-al-antigeno-de-superficie-del-virus-de-la-hepatitis-b-en-animales-no-respondedores-a-dicho-antigeno-implicaciones-en-la-prevencion-y-en-el-tratamiento-de-la-hepatitis\/","title":{"rendered":"Induccion de anticuerpos frente al antigeno de superficie del virus de la hepatitis b en animales no respondedores a dicho antigeno. implicaciones en la prevencion y en el tratamiento de la hepatitis b."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sandra Hervas Stubbs <\/strong><\/h2>\n<p>La falta de respuesta humoral frente a un antigeno, debida a una pobre induccion de linfocitos t \u00abhelper\u00bb, puede ser soslayada mediante la inmunizacion conjunta con el antigeno y un peptido determinante t \u00abhelper\u00bb (dth) bien reconocido por las moleculas mhc-ii del sujeto no respondedor. En efecto, ratones sjl (con restriccion h-2s) no respondedores a la vacuna de la hepatitis b-antigeno de superficie del virus de la hepatitis b (hbsag) formado solo por region s-, producen anticuerpos (ac) anti-hbs tras la inmunizacion conjunta con hbsag y un peptido dth con restriccion h-2s. Esta estrategia es tambien capaz de inducir ac anti-superficie en un modelo animal de hepatitis cronica b: el de la marmota cronicamente infectada por el virus de la hepatitis de la marmota (whv). Al igual que ocurre en humanos, en el suero de los portadores cronicos del whv. No se detectan normalmente ac anti-superficie. La co-inmunizacion con whsag (equivalente al hbsag en el hombre) y un peptido dth adecuado, indujo ac anti-whs en marmotas cronicamente infectadas por whv, redujo los niveles sericos del dna viral y reactivo la respuesta inmune frente a los hepatocitos infectados. Sin embargo, de las dos marmotas que produjeron los titulos de ac anti-whs mas altos, una murio de hepatitis fulminante y la otra sufrio severo da\u00f1o hepatico. Estos resultados podrian tener aplicaciones importantes en la prevencion y en el tratamiento de la hepatitis b. No obstante, desde el punto de vista terapeutico, falta aun por aprender como modular la respuesta inmune inducida.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Induccion de anticuerpos frente al antigeno de superficie del virus de la hepatitis b en animales no respondedores a dicho antigeno. implicaciones en la prevencion y en el tratamiento de la hepatitis b.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Induccion de anticuerpos frente al antigeno de superficie del virus de la hepatitis b en animales no respondedores a dicho antigeno. implicaciones en la prevencion y en el tratamiento de la hepatitis b. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sandra Hervas Stubbs <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Borras Cuesta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas M. Prieto Valtue\u00f1a <\/li>\n<li>Luis EnJuan es Sanchez (vocal)<\/li>\n<li>Natalia Mar\u00eda Lopez Moratalia (vocal)<\/li>\n<li>Joan Ignasi Esteban Mur (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sandra Hervas Stubbs La falta de respuesta humoral frente a un antigeno, debida a una pobre induccion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,32218,1737,2612,17749],"tags":[18184,15059,13798,5594,13081,48934],"class_list":["post-32462","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-formacion-de-anticuerpos","category-inmunologia","category-inmunoquimica","category-navarra","tag-francisco-borras-cuesta","tag-jesus-m-prieto-valtuena","tag-joan-ignasi-esteban-mur","tag-luis-enjuan-es-sanchez","tag-natalia-maria-lopez-moratalia","tag-sandra-hervas-stubbs"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/32462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=32462"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/32462\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=32462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=32462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=32462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}