{"id":32495,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":""},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"efectos-vasculares-y-renales-del-bloqueo-de-los-receptores-at1-de-angiotensina-ii-en-la-rata-espontaneamente-hipertensa-participacion-de-los-receptores-at2-el-oxido-nitrico-las-prostaglandinas-y-la","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efectos-vasculares-y-renales-del-bloqueo-de-los-receptores-at1-de-angiotensina-ii-en-la-rata-espontaneamente-hipertensa-participacion-de-los-receptores-at2-el-oxido-nitrico-las-prostaglandinas-y-la\/","title":{"rendered":"Efectos vasculares y renales del bloqueo de los receptores at1 de angiotensina ii en la rata espontaneamente hipertensa: participacion de los receptores at2, el oxido nitrico, las prostaglandinas y las cininas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Mu\u00f1oz Garcia <\/strong><\/h2>\n<p>La angiotensina ii (aii) participa en el desarrollo de la hipertension arterial. Las principales acciones de la aii las realiza uniendose a sus receptores especificos at1.  las acciones de la aii mediadas por sus receptores at2 no son bien conocidas actualmente, tambien se han demostrado numerosas interrelaciones entre el sistema renina-angiotensina, el oxido nitrico (no), las prostaglandinas (pgs) y las cininas. El presente trabajo estudia los efectos agudos y a corto plazo del antagonista de los receptores at1, losartan, sobre la presion arterial (pa) y la funcion renal, asi como su efecto sobre la reactividad vascular in vitro en la rata espontaneamente hipertensa (shr). Asimismo, estudia la participacion de los receptores at2, el no, las pgs y las cininas en dichos efectos. La administracion de losartan redujo la pa, incremento el flujo urinarinario (vo), la excrecion urinaria de sodio (unav) y la hemodinamica renal. Por otro lado, losartan redujo la respuesta constrictora inducida por fenilefrina en anillos aorticos de shr. El bloqueo de los receptores at2, redujo los efectos diuretico, natriuretico e hipotensor de losartan y anulo su efecto sobre la respuesta a fenilefrina. La inhibicion de la sintesis del no redujo los efectos de losartan sobre la pa, la hemodinamica renal y la contraccion a finilefrina. Las acciones de losartan sobre la funcion excretora renal y la hemodinamica renal fueron reducidas al inhibir la sintesis de pgs y bloquear los receptores b2 de cininas, sin embargo, solo las pgs y no las cininas participan en los efectos de losartan sobre la pa. La reduccion en la respuesta constrictora a fenilefrina inducida por losartan no se modifico durante la inhibicion de las pgs ni durante el bloqueo de los receptores de cininas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos vasculares y renales del bloqueo de los receptores at1 de angiotensina ii en la rata espontaneamente hipertensa: participacion de los receptores at2, el oxido nitrico, las prostaglandinas y las cininas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos vasculares y renales del bloqueo de los receptores at1 de angiotensina ii en la rata espontaneamente hipertensa: participacion de los receptores at2, el oxido nitrico, las prostaglandinas y las cininas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Mu\u00f1oz Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Victoria Cachofeiro Ramos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Edurne Cenarruzabeitia Sagarminaga <\/li>\n<li>Carlos F\u00e9lix S\u00e1nchez Ferrer (vocal)<\/li>\n<li>Ana Barber C\u00e1rcamo (vocal)<\/li>\n<li> Ruilope Urioste Luis Miguel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Mu\u00f1oz Garcia La angiotensina ii (aii) participa en el desarrollo de la hipertension arterial. Las principales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,675,17749,226],"tags":[17999,5261,17998,36642,89506,39035],"class_list":["post-32495","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-fisiologia-animal","category-navarra","category-zoologia","tag-ana-barber-carcamo","tag-carlos-felix-sanchez-ferrer","tag-edurne-cenarruzabeitia-sagarminaga","tag-maria-victoria-cachofeiro-ramos","tag-raquel-munoz-garcia","tag-ruilope-urioste-luis-miguel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/32495","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=32495"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/32495\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=32495"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=32495"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=32495"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}