{"id":3251,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/un-nuevo-metodo-in-vivo-para-comparar-la-potencia-de-los-hipoglucemiantes-orales-y-su-utilidad-en-la-clinica\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"un-nuevo-metodo-in-vivo-para-comparar-la-potencia-de-los-hipoglucemiantes-orales-y-su-utilidad-en-la-clinica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/un-nuevo-metodo-in-vivo-para-comparar-la-potencia-de-los-hipoglucemiantes-orales-y-su-utilidad-en-la-clinica\/","title":{"rendered":"Un nuevo metodo in vivo para comparar la potencia de los hipoglucemiantes orales y su utilidad en la clinica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Ampudia Blasco <\/strong><\/h2>\n<p>Se investigaron in vivo las propiedades farmacodinamicas de la glibenclamida en comparacion a las de un nuevo farmaco conocido como ag-ee 623 zw mediante la tecnica del clamp euglicemico. Nueve sujetos varones sanos fueron conectados al biostator en ayunas, y despues de un periodo basal de 30 min se les suministro una dosis de glibenclamida (1,75,3,5 o 7,0mg) o de ag-ee 623 zw (1,0,2,0 o 4,0 mg). Las concentraciones de glucosa en sangre se mantuvieron mediante clamp a un 10% por debajo de la glucemia basal. El ritmo de infusion de glucosa se registro durante un periodo de 10 h despues de la administracion de la tableta correspondiente. La infusion maxima de glucosa despues de la administracion de glibenclamida fue un 40% mayor en comparacion con el ag-ee 623 zw (1,75 vs. 1,0 mg, 3,5 vs. 2,0 mg, 7,0 mg vs.  4,0 mg, respectivamente), y se alcanzo despues de 3-3,5 h. Con la glibenclamida, el area bajo de la curva de infusion de glucosa y el incremento maximo de la respuesta de insulina en el suero fueron mayores un 25-45% y un 30%, respectivamente, en comparacion con el ag-ee 623 zw, cuando se evaluaron las dosis menor, media y mayor de ambos farmacos. Sin embargo, cuando el area bajo la curva de infusion de glucosa se represento frente al area bajo la curva de insulina, se demostro una relacion linear con el incremento de la dosis de ambos compuestos. De hecho; ambos farmacos fueron equipotentes cuando se compararon por unidad de peso molecular. El indice hipoglucemiante de la glibenclamida y del ag-ee 623 zw (infusion de glucosa integrada dividida por la respuesta insulinica integrada) expresada por umol de farmaco revelo una relacion curvilinear inversa con el incremento de la dosis. Esta nueva metodolog\u00eda permite la cuantificacion y la comparacion de las caracteristicas farmacodinamicas de los hipoglucemiantes orales en condiciones estandard de experimentacion.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Un nuevo metodo in vivo para comparar la potencia de los hipoglucemiantes orales y su utilidad en la clinica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Un nuevo metodo in vivo para comparar la potencia de los hipoglucemiantes orales y su utilidad en la clinica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Ampudia Blasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Leiva Hidalgo Alberto De<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francesc Gonz\u00e1lez Sastre <\/li>\n<li>Jos\u00e9 Enrique Campillo \u00e1lvarez (vocal)<\/li>\n<li>Rafael Carmena Rodriguez (vocal)<\/li>\n<li>Jos\u00e9 M Pou Torell\u00f3 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Ampudia Blasco Se investigaron in vivo las propiedades farmacodinamicas de la glibenclamida en comparacion a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,851,139],"tags":[13646,13644,1743,13647,13645,11685],"class_list":["post-3251","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-endocrinologia","category-medicina-interna","tag-francesc-gonzalez-sastre","tag-francisco-javier-ampudia-blasco","tag-jose-enrique-campillo-alvarez","tag-jose-m-pou-torello","tag-leiva-hidalgo-alberto-de","tag-rafael-carmena-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/3251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=3251"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/3251\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=3251"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=3251"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=3251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}