{"id":32530,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-sintesis-y-evaluacion-biologica-preliminar-de-nuevos-agentes-antidepresivos\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"diseno-sintesis-y-evaluacion-biologica-preliminar-de-nuevos-agentes-antidepresivos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/diseno-sintesis-y-evaluacion-biologica-preliminar-de-nuevos-agentes-antidepresivos\/","title":{"rendered":"Dise\u00f1o, sintesis y evaluacion biologica preliminar de nuevos agentes antidepresivos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Irache Visiers Guelbenzu <\/strong><\/h2>\n<p>Hay evidencia experimental que muestra que un tratamiento prolongado con antidepresivos produce hipersensibilidad de los receptores 5-ht1a postsinapticos junto a hiposensibilidad de los 5-ht1a presinapticos.  este aumento de la sensibilidad de los receptores postsinapticos solo ocurre tras un tratamiento prolongado con el antidepresivo, y es independiente de los efectos inhibidores de la recaptacion de monoaminas.  parece ser que se desencadena un mecanismo de feed-back, en el cual es fundamental el papel de los autorreceptores somatodendriticos 5-ht1a. La funcion de estos receptores es reprimir la actividad de las neuronas serotoninergicas. Cuando se incrementa la concentracion extracelular de 5-ht, se produce una activacion del receptor 5-ht1a. Como consecuencia se reduce la velocidad de disparo neuronal, la sintesis de 5-ht, y la liberacion a nivel terminal. La administracion repetida de un ssri produce una desensibilizacion de estos receptores, de modo que cuando esta tiene lugar, el antidepresivo ejerce su mision de aumentar la concentracion de 5-ht en la hendidura sinaptica, sin que se anule por el mecanismo de retroalimentacion. El tiempo que tarda en instaurarse el efecto terapeutico es el tiempo que tarda en producirse esta desensibilizacion de los receptores 5-ht1a.  basados en estos estudios, se lleva a cabo el dise\u00f1o de una serie de moleculas, que tras ser sintetizadas han sido evaluadas farmacologicamente. El estudio de los datos de actividad conduce a nuevas modificaciones estructurales en las moleculas iniciales, que son sometidas a nuevas pruebas biologicas. Los ensayos biologicos preliminares realizados consisten fundamentalmente en ensayos de desplazamiento de radioligandos, empleando membranas neuronales de corteza frontal de rata.  los resultados son interpretados mediante estudios de distribucion de pem, y de homo y lumo, utilizando una estacion de trabajo silicon grafics modelo elan 4000 iris indigo, pr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, sintesis y evaluacion biologica preliminar de nuevos agentes antidepresivos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, sintesis y evaluacion biologica preliminar de nuevos agentes antidepresivos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Irache Visiers Guelbenzu <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Monge Vega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Pilar Fernandez Otero <\/li>\n<li>Mar\u00eda Font Arellano (vocal)<\/li>\n<li>Francisco Zaragoza Garcia (vocal)<\/li>\n<li>Ana Boch Rovira (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Irache Visiers Guelbenzu Hay evidencia experimental que muestra que un tratamiento prolongado con antidepresivos produce hipersensibilidad de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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