{"id":32531,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-administracion-cronica-de-midazolam-en-el-hipocampo-de-ratas-viejas\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"efectos-de-la-administracion-cronica-de-midazolam-en-el-hipocampo-de-ratas-viejas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-la-administracion-cronica-de-midazolam-en-el-hipocampo-de-ratas-viejas\/","title":{"rendered":"Efectos de la administracion cronica de midazolam en el hipocampo de ratas viejas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ysasi Fernandez De Bobadilla Alejandro <\/strong><\/h2>\n<p>La posible neurotoxidad del midazolam (mdz), imidazolbenzodiacepina que va siendo utilizada cada vez con mayor frecuencia en tratamientos cronicos, no ha sido todavia investigada. El objeto de nuestro estudio es investigar si el mdz administrado cronicamente produce alguna alteracion neuronal en el hipocampo. Este estudio lo hemos realizado en ratas wistar de 24 meses (la mayor parte de los pacientes que toman mdz de forma continuada, suelen pertenecer a la tercera edad), y el tiempo de tratamiento ha sido 1\/8 de la vida de estas ratas, equivalente a 10 a\u00f1os en nuestra especie). Se han utilizado 50 ratas distribuidas en 3 grupos: grupo control, de 10 ratas que solo recibio suero fisiologico y 2 grupos de 20 ratas cada uno, tratados con mdz por via oral, uno con 1 mg \/kg\/dia y otro 3 mg\/kg\/dia. Los animales, bajo anestesia profunda fueron perfundidos con paraformaldehido al 4% y el cerebro, una vez extraido, continuo su fijacion en liquido de bouin. Tras la fijacion se procesaron para su inclusion en parafina, se seccionaron coronalmente de forma seriada a 7 um y se ti\u00f1eron por el metodo de nissl. Uno de cada 5 cortes se destino para la demostracion de las neuronas parvalbumina positivas. La accion del mdz sobre el hipocampo la hemos juzgado, principalmente, mediante e recuento neuronal y la morfometria (cariometria y citometria).  los resultados obtenidos han puesto de manifiesto un aumento del numero de neuronas oscuras y picnoticas en todas la subdivisiones del hipocampo de los animales tratados con mdz, llegando a ser significativas en gd, ca1 y ca4. El comportamiento de los animales en el test de evitacion pasiva no evidencio alteracion en la memoria, tanto en la fijacion como en la retencion y evocacion del estimulo aversivo. La evolucion ponderal de los animales tratados puso de manifiesto una perdida de peso que alcanzo significacion estadistica en los grupos tratados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la administracion cronica de midazolam en el hipocampo de ratas viejas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la administracion cronica de midazolam en el hipocampo de ratas viejas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ysasi Fernandez De Bobadilla Alejandro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Gonzalo Sanz  Luis Mar\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Velayos Jorge <\/li>\n<li>Francisco Carrascosa Moreno (vocal)<\/li>\n<li>Jos\u00e9 Manuel Gimenez Amaya (vocal)<\/li>\n<li>Ricardo Insausti Serrano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ysasi Fernandez De Bobadilla Alejandro La posible neurotoxidad del midazolam (mdz), imidazolbenzodiacepina que va siendo utilizada cada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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