{"id":32812,"date":"1997-01-01T00:00:00","date_gmt":"1997-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-apoptosis-y-proliferacion-celular-en-linfomas-no-hodgkinianos-valor-diagnostico-y-pronostico\/"},"modified":"1997-01-01T00:00:00","modified_gmt":"1997-01-01T00:00:00","slug":"estudio-de-la-apoptosis-y-proliferacion-celular-en-linfomas-no-hodgkinianos-valor-diagnostico-y-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-apoptosis-y-proliferacion-celular-en-linfomas-no-hodgkinianos-valor-diagnostico-y-pronostico\/","title":{"rendered":"Estudio de la apoptosis y proliferacion celular en linfomas no hodgkinianos. valor diagnostico y pronostico."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Macia Virgili Jos\u00e9 M. <\/strong><\/h2>\n<p>Nuestro objetivo es estudiar la apoptosis y la proliferacion de las celulas tumorales en el momento del diagnostico de pacientes con linfoma no hodgkiniano (lnh) y en grupos homogeneos de los mismos, y analizar si existen diferencias entre las distintas entidades clinico-histologicas, presentan relacion con parametros pronosticos clasicos y poseen valor pronostico en esta enfermedad.  hemos estudiado 139 pacientes diagnosticados de lnh desde 1975 a 1995. Los datos clinicos, histologicos y pronosticos de los pacientes resultaron similares a los de otras series publicadas. De cada enfermo se han recogido: numero de historia, nombre, edad, sexo, fecha de diagnostico, diagnostico histologico (segun clasificacion de la working formulation), afectacion extranodal, sintomas b, ecog, tama\u00f1o del tumor y estadio, ldh, beta-2-microglobulina, tnf-alfa y ferritina, respuesta, tolerancia al tratamiento, tiempo libre de enfermedad y de supervivencia. El estudio de proliferacion y muerte celular se ha realizado sobre el tejido obtenido al diagnostico y consistio en:  cuantificacion de la proporcion de celulas en apoptosis por medio de una tecnica basada en la reaccion tunel y contaje del porcentaje de celulas en fase s mediante citometria de flujo sobre muestras desparafinadas.  la apoptosis y la proliferacion fueron significativamente superiores cuanto mayor fue el grado de malignidad del lnh y en los lnh extranodales. En cada uno de los grupos de malignidad histologica, la apoptosis seguia siendo mayor en los pacientes con afectacion extranodal. Ello pone de manifiesto un comportamiento diferente del fenomeno de la apoptosis en los tumores linfoides de localizacion extranodal, independiente del tipo histologico y del grado de proliferacion. La apoptosis podria representar un mecanismo defensivo frente a unas celulas que estan predispuestas a una proliferacion anormal. Hemos encontrado que valores altos de apoptosis y fase s se relacionan c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la apoptosis y proliferacion celular en linfomas no hodgkinianos. valor diagnostico y pronostico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la apoptosis y proliferacion celular en linfomas no hodgkinianos. valor diagnostico y pronostico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Macia Virgili Jos\u00e9 M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Lleida<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elies Campo Guerri<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Enrique Esquerda Colell <\/li>\n<li>Jordi Sans-sabrafen (vocal)<\/li>\n<li>Benet Nomdedeu Tobella (vocal)<\/li>\n<li>Soledad Woesner Casas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Macia Virgili Jos\u00e9 M. Nuestro objetivo es estudiar la apoptosis y la proliferacion de las celulas tumorales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,218,18842,139,347],"tags":[18864,18862,90073,18863,90072,90074],"class_list":["post-32812","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-hematologia","category-lleida","category-medicina-interna","category-oncologia-clinica","tag-benet-nomdedeu-tobella","tag-elies-campo-guerri","tag-jordi-sans-sabrafen","tag-jose-enrique-esquerda-colell","tag-macia-virgili-jose-m","tag-soledad-woesner-casas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/32812","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=32812"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/32812\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=32812"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=32812"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=32812"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}