{"id":3282,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/amiloidosis-en-dialisis-estudio-mediante-sintesis-in-vitro-de-beta2-microglobulina-relacion-con-la-activacion-linfocitaria-y-liberacion-de-citokinas\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"amiloidosis-en-dialisis-estudio-mediante-sintesis-in-vitro-de-beta2-microglobulina-relacion-con-la-activacion-linfocitaria-y-liberacion-de-citokinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/amiloidosis-en-dialisis-estudio-mediante-sintesis-in-vitro-de-beta2-microglobulina-relacion-con-la-activacion-linfocitaria-y-liberacion-de-citokinas\/","title":{"rendered":"Amiloidosis en dialisis. estudio mediante sintesis \u00abin vitro\u00bb de beta2-microglobulina. relacion con la activacion linfocitaria y liberacion de citokinas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Federico Cofan Pujol <\/strong><\/h2>\n<p>La amiloidosis asociada a la dialisis, se caracteriza por el deposito tisular de beta2-microglobulina (b2m). Afecta fundamentalmente a pacientes con insuficiencia renal cronica, sometidos a dialisis durante periodos prolongados de tiempo y se manifiesta principalmente con un cuadro osteoarticular. La patogenia es multifactorial.  un aspecto muy controvertido es la influencia de la biocompatibilidad de la tecnica dialitica en los niveles de b2m. Se ha especulado que los linfocitos uremicos de pacientes dializados con membranas no-biocompatibles (cuprophan) sintetizan mas b2m respecto a las membranas biocompatibles. Este aspecto no ha sido realmente demostrado. El objetivo de esta tesis consiste en \u00abevaluar la existencia de una sintesis activa de b2m inducida por las tecnicas dialiticas y analizar la relacion existente con la activacion linfocitaria y la liberacion de citokinas\u00bb. Se investigo la influencia del tipo de membrana de hemodialisis utilizada y de la dialisis peritoneal. Se estudian 10 pacientes en dialisis peritoneal (dpac) y 10 pacientes en hemodialisis (hd) dializados en grupos cruzados con la membrana no-biocompatible de cuprophan (cup) y la membrana biocompatible de poliacrilonitrilo (pan-a69). Se realizo cultivo de celulas linfomononucleares de sangre periferica en situacion basal y tras estimulacion (interferon y fitohemaglutinina) determinando en el sobrenadante b2m, tnf, y il-1 y neopterina. Se estudio por citofluorometria la activacion linfocitaria \u00abin vivo\u00bb mediante la expresion en la membrana linfocitaria del receptor de il-2 y de las moleculas hla de clase ii. Tras analizar los resultados se observa que la mejor biocompatibilidad de la tecnica dialitica utilizada se manifiesta por una menor produccion de citokinas, un menor grado de activacion linfocitaria y una mayor capacidad de sintesis-liberacion de b2m y neopterina. La mayor produccion de b2m y neopterina en dpac refleja un estado inmunologico mas preser<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Amiloidosis en dialisis. estudio mediante sintesis \u00abin vitro\u00bb de beta2-microglobulina. relacion con la activacion linfocitaria y liberacion de citokinas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Amiloidosis en dialisis. estudio mediante sintesis \u00abin vitro\u00bb de beta2-microglobulina. relacion con la activacion linfocitaria y liberacion de citokinas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Federico Cofan Pujol <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Caralps Riera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miquel Vilardell Tarres <\/li>\n<li>Evarist Feliu Frasnedo (vocal)<\/li>\n<li>Ricardo Pujol Borrell (vocal)<\/li>\n<li>Josep Mar\u00eda Campistol Plana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Federico Cofan Pujol La amiloidosis asociada a la dialisis, se caracteriza por el deposito tisular de beta2-microglobulina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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