{"id":32930,"date":"1997-10-03T00:00:00","date_gmt":"1997-10-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/quimioterapia-complementaria-del-cancer-colorrectal-con-mitomicina-c-y-ftorafur\/"},"modified":"1997-10-03T00:00:00","modified_gmt":"1997-10-03T00:00:00","slug":"quimioterapia-complementaria-del-cancer-colorrectal-con-mitomicina-c-y-ftorafur","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/quimioterapia-complementaria-del-cancer-colorrectal-con-mitomicina-c-y-ftorafur\/","title":{"rendered":"Quimioterapia complementaria del cancer colorrectal con mitomicina c y ftorafur"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enric Garcia Restoy <\/strong><\/h2>\n<p>Objetivo principal: investigar si el tratamiento complementario postoperatorio con mitomicina-c(mmc) y ftorafur (ft) aumenta el intervalo libre de enfermedad (ile) y la supervivencia global en los pacientes intervenidos de cancer colorrectal.  objetivo secundario: evaluar la toxicidad de la pauta de quimioterapia empleada. Pacientes y metodo: se han estudiado 175 pacientes con cancer de colorrectal en el estadio b2,c1 o c2 de la clasificaci\u00f3n de astler y coller. En 114 casos se trataba de c\u00e1ncer de colon y en 61 de cancer de recto. Mediante aleatorizaci\u00f3n, 87 casos fueron asignados al grupo de quimioterapia adyuvante postoperatria con mmc(20 mg\/m2 por via i.V. Cada 6 semanas, cuatro ciclos) y 88 al grupo control tratado solamente con cirugia. El analisis del intervalo libre de enfermedad y supervivencia global se ha basado en el modelo de regresi\u00f3n de cox. Resultados: con una mediana del tiempo de seguimiento de 31 meses (extremos: 4-97), no se demuestran diferencias entre el grupo control y el grupo tratado con quimioterapia en cuanto a ile ni supervivencia global. Sin embargo, en los pacientes con cancer de recto, tanto el ile como la supervivencia global han sido superiores en el grupo de quimioterapia adyuvante, tras ajustar por el estadio (p=0,009 y p=0,04, respectivamente) conun riesgo relativo con recidiva de 0,39 (ic 95%: 0,19-0,80) y de muerte de 0,40(ic 95%: 0,20-0,90). La pauta de quimioterapia ha sido bien tolerada, aunque 4 pacientes han presentado sindrome hemolitico uremico y un paciente insuficiencia renal cronica sin hemolisis y afectacion pulmonar intersticial.  conclusiones: el tratamiento adyuvante con mmc y ft puede mejorar el ile y la supervivencia del c\u00e1ncer rectal en estadios b2 y c.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Quimioterapia complementaria del cancer colorrectal con mitomicina c y ftorafur<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Quimioterapia complementaria del cancer colorrectal con mitomicina c y ftorafur <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enric Garcia Restoy <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/03\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Estape Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cristobal Pera blanco-morales <\/li>\n<li>joan Sala pedros (vocal)<\/li>\n<li>jordi Sans-sabrafen (vocal)<\/li>\n<li>albert Abad esteve (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enric Garcia Restoy Objetivo principal: investigar si el tratamiento complementario postoperatorio con mitomicina-c(mmc) y ftorafur (ft) aumenta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,160,9,17,3369],"tags":[58686,146,90269,90271,90073,90270],"class_list":["post-32930","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-bioquimica","category-ciencias-medicas","category-quimica","category-quimioterapia","tag-albert-abad-esteve","tag-cristobal-pera-blanco-morales","tag-enric-garcia-restoy","tag-joan-sala-pedros","tag-jordi-sans-sabrafen","tag-jorge-estape-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/32930","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=32930"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/32930\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=32930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=32930"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=32930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}