{"id":32939,"date":"2018-03-09T09:29:48","date_gmt":"2018-03-09T09:29:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-lesion-hepatica-por-isquemia-reperfusion-en-ratas-sometidas-a-precondicionamiento-isquemico\/"},"modified":"2018-03-09T09:29:48","modified_gmt":"2018-03-09T09:29:48","slug":"estudio-de-la-lesion-hepatica-por-isquemia-reperfusion-en-ratas-sometidas-a-precondicionamiento-isquemico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-lesion-hepatica-por-isquemia-reperfusion-en-ratas-sometidas-a-precondicionamiento-isquemico\/","title":{"rendered":"Estudio de la lesion hepatica por isquemia-reperfusion en ratas sometidas a precondicionamiento isquemico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Peralta Uroz <\/strong><\/h2>\n<p>El precondicionamiento isqu\u00e9mico, inducido por cortos periodos de isquemia reperfusi\u00f3n, protege al \u00f3rgano frente a subsiguientes y m\u00e1s prolongados periodos de estr\u00e9s isqu\u00e9mico. Teniendo en cuenta que a nivel de coraz\u00f3n, el precondicionamiento protege de la lesi\u00f3n por isquemia reperfusi\u00f3n, los objetivos del presente estudio son los siguientes: 1) valorar la importancia del precondicionamiento isqu\u00e9mico en la prevenci\u00f3n de la lesi\u00f3n por isquemia reperfusi\u00f3n hep\u00e1tica; 2) investigar el papel de los mediadores involucrados, as\u00ed como los mecanismos implicados en este proceso. Para abordar los objetivos propuestos: 1) testar diferentes tiempos de isquemia; 2) estudio del efecto protector del precondicionamiento en el tiempo de isquemia seleccionado.  los animales de experimentaci\u00f3n fueron sometidos a diferentes tiempos de isquemia (15-30-60-90) minutos, sujetos o no a precondicionamiento previo, inducido por 10 minutos de isquemia y 10 minutos de reperfusi\u00f3n. Para la puesta a punto del precondicionamiento, se determinaron como par\u00e1metros de lesi\u00f3n tisular; ast, alt y ldh, estudio histol\u00f3gico y flujo.  para estudiar el efecto protector del precondicionamiento en el tiempo de isquemia seleccionado (90 minutos): se analizaron los mediadores de la inflamaci\u00f3n que podr\u00edan estar implicados en el precondicionamiento como eicosanoides, neutr\u00f3filos, rlo y enzimas antioxidantes (sod), no, adenosina y endotelinas, mediante la administraci\u00f3n y\/o inhibici\u00f3n de los mediadores potencialmente implicados en el proceso, los par\u00e1metros de lesi\u00f3n tisular (ast, alt y ldh) y flujo, y an\u00e1lisis bioqu\u00edmicos e histol\u00f3gicos.  seg\u00fan los resultados obtenidos, se puede concluir:  1) el precondicionamiento isqu\u00e9mico es un mecanismo potector de la lesi\u00f3n asociada a isquemia reperfusi\u00f3n hep\u00e1tica. 2) en el precondicionamiento hep\u00e1tico est\u00e1n implicados la adenosina, el no y las endotelinas. 3) el mecanismo propuesto para el efecto<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la lesion hepatica por isquemia-reperfusion en ratas sometidas a precondicionamiento isquemico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la lesion hepatica por isquemia-reperfusion en ratas sometidas a precondicionamiento isquemico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Peralta Uroz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/03\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Georgina Hotter Corripio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mari\u00ed\u00a0 Alemany lamana <\/li>\n<li>joan Serratosa sarda (vocal)<\/li>\n<li>Emilio Gelpi monteyn (vocal)<\/li>\n<li>Juan Rod\u00e9s teixidor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Peralta Uroz El precondicionamiento isqu\u00e9mico, inducido por cortos periodos de isquemia reperfusi\u00f3n, protege al \u00f3rgano frente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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