{"id":32982,"date":"2018-03-09T09:29:52","date_gmt":"2018-03-09T09:29:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/paper-de-los-leucotrienos-en-la-sindrome-de-la-respuesta-inflamatoria-sistemica-efecto-de-la-inhibicion-de-la-5-lipoxigenasa\/"},"modified":"2018-03-09T09:29:52","modified_gmt":"2018-03-09T09:29:52","slug":"paper-de-los-leucotrienos-en-la-sindrome-de-la-respuesta-inflamatoria-sistemica-efecto-de-la-inhibicion-de-la-5-lipoxigenasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/paper-de-los-leucotrienos-en-la-sindrome-de-la-respuesta-inflamatoria-sistemica-efecto-de-la-inhibicion-de-la-5-lipoxigenasa\/","title":{"rendered":"Paper de los leucotrienos en la sindrome de la respuesta inflamatoria sistemica . efecto de la inhibicion de la 5-lipoxigenasa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Merce Amat Fabregat <\/strong><\/h2>\n<p>La sindrome de la respuesta inflamatoria sistematica (sris) engloba un conjunto de manifestaciones como la sepsi o la sindrome del distress respiratorio del adulto (sdra). Actualmente no hay una terapeutica adecuada para estos pacientes. En la memoria se estudian un total de 40 pacientes con sris. Tambi\u00e9n se caracterizan un nuevo farmaco antiflamatori, bobel-24. Resultados.: Los niveles de leucotrieno bu estan elevados en los pacientes con sdra o los septicos que mueren, siendo en leucotrieno bu estan se sdra. Los niveles de il-8 se encuentran elevados en los pacientes con sdra. Los sdra. Los niveles de il-8 y leucotrienos se encuentran elevados en los pacientes con sdra. Los niveles de ll-8 y leucotrieno b4 analizados conjuntamente son marcadores pronostico de sdra, sensibilidad del 95% y una especificidad del 68%. El bobel-24 es inhibidor de la 5-lirxigenasa, invitro, ex-vivo y in vivo, potencia del mismo orden que el zileuton. En un modelo de sris inducido por \u00abplatelet activaling factor\u00bb en rata, la inhibicion de la sintesis de los leucotrienos provoca un incremento del tiempo de super vivencia, del porcentaje de mortalidad y una mejora macroscopica y microscopica del pumon. Dicho efecto va acompa\u00f1ado de una inhibici\u00f3n de la sintesi de leucotrienos en el tejido pulmonar. Estos resultados confirman la implicacion de los leucotrienos en la sris la vitilidad del bobel-24.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Paper de los leucotrienos en la sindrome de la respuesta inflamatoria sistemica . efecto de la inhibicion de la 5-lipoxigenasa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Paper de los leucotrienos en la sindrome de la respuesta inflamatoria sistemica . efecto de la inhibicion de la 5-lipoxigenasa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Merce Amat Fabregat <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/06\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Vila Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Llobera sande <\/li>\n<li>joaquin Bonal de falgas (vocal)<\/li>\n<li>salvador Benito vales (vocal)<\/li>\n<li>joan Rosello catafau (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Merce Amat Fabregat La sindrome de la respuesta inflamatoria sistematica (sris) engloba un conjunto de manifestaciones como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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