{"id":32986,"date":"2018-03-09T09:29:53","date_gmt":"2018-03-09T09:29:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesi-y-actividad-biologica-de-analogos-del-acido-510-dideaza-5678-tetrahidrofolico-ddathf\/"},"modified":"2018-03-09T09:29:53","modified_gmt":"2018-03-09T09:29:53","slug":"sintesi-y-actividad-biologica-de-analogos-del-acido-510-dideaza-5678-tetrahidrofolico-ddathf","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesi-y-actividad-biologica-de-analogos-del-acido-510-dideaza-5678-tetrahidrofolico-ddathf\/","title":{"rendered":"Sintesi y actividad biologica de analogos del acido 5,10-dideaza-5,6,7,8- tetrahidrofolico (ddathf)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Blanca Martinez Teipel <\/strong><\/h2>\n<p>Se aplica la metodolog\u00eda desarrollada por el equipo para la s\u00edntesis de piridol   2,3-d pirimidinas a la obtenci\u00f3n de an\u00e1logos del \u00e1cido 5,10-dideaza-5,6,7,8-tetrahidrof\u00f3lico (ddthf). Se obtiene una familia de an\u00e1logos 2,4-diamino sustituidos a partir de los correspondientes 2-metoxi-6-oxo-1,4,5,6- tetrahidropirin-3-carbonitrilos por ciclaci\u00f3n con guanidina, posterior hidr\u00f3lisis del grupo ester presente en el anillo benc\u00e9nico y acoplamiento con l-glutamato de dimetilo, en un itinerario sint\u00e9tico que comprende un total de seis etapas a partir de productos comerciales.  se ha ensayado la actividad de los compuestos finales frente a c\u00e9lulas leuc\u00e9micas humanas ccrf-cem, resultando inactivos.  se estudia, adem\u00e1s, la sustituci\u00f3n por cianamida del metoxilo de los 2-metoxipiridin-3-carbonitrilos mencionados anteriormente, as\u00ed como la posterior ciclaci\u00f3n con bromuro de hidr\u00f3geno de los sistemas 1,5-dinitr\u00edlos resultantes, observ\u00e1ndose por primera vez en la experiencia del equipo la influencia de la naturaleza del sustituyente en la regioselectividad de la ciclaci\u00f3n.  finalmente, la reducci\u00f3n selectiva con borano en tetrahidrofurano de la lactama presente en los compuestos obtenidos abre una nueva v\u00eda de s\u00edntesis de antifolatos con demostrada actividad antineopl\u00e1sica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesi y actividad biologica de analogos del acido 5,10-dideaza-5,6,7,8- tetrahidrofolico (ddathf).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesi y actividad biologica de analogos del acido 5,10-dideaza-5,6,7,8- tetrahidrofolico (ddathf). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Blanca Martinez Teipel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Ram\u00f3n llull<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/06\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ignacio Borrell Bilbao<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Irurre perez <\/li>\n<li>angels Fabra fres (vocal)<\/li>\n<li>Miguel \u00e1ngel Peric\u00ed\u00a0s brondo (vocal)<\/li>\n<li>llu\u00eds Comellas riera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Blanca Martinez Teipel Se aplica la metodolog\u00eda desarrollada por el equipo para la s\u00edntesis de piridol 2,3-d [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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