{"id":33061,"date":"1997-03-10T00:00:00","date_gmt":"1997-03-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mutaciones-del-oncogen-supresor-p53-en-tumores-vesicales-correlacion-con-otros-factores-pronosticos\/"},"modified":"1997-03-10T00:00:00","modified_gmt":"1997-03-10T00:00:00","slug":"mutaciones-del-oncogen-supresor-p53-en-tumores-vesicales-correlacion-con-otros-factores-pronosticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mutaciones-del-oncogen-supresor-p53-en-tumores-vesicales-correlacion-con-otros-factores-pronosticos\/","title":{"rendered":"Mutaciones del oncogen supresor p53 en tumores vesicales: correlacion con otros factores pronosticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Ignacio Abad Vivas Perez <\/strong><\/h2>\n<p>Estudio de las mutaciones del gen p53 y expresi\u00f3n de la oncoprote\u00edna p53 en 75 tumores vesicales. Mediante pcr y posterior an\u00e1lisis secuencial realizado con un secuenciador de dna tipo \u00ab\u00bbapplied ryosistem\u00bb\u00bb 377&#8243;\u00bb. La expresi\u00f3n de oncoprote\u00edna p53 se realiz\u00f3 mediante citometria de flujo. Las mutaciones del gen p53 se encontraron en el 39% de las muestras. El tipo m\u00e1s frecuente de mutaci\u00f3n fueron las puntuales (79%). La localizaci\u00f3n de las mutaciones fu\u00e9 en los exones 5 (8 casos), 6 (6), 7 (9) y 8 (6). Las mutaciones del gen p53 seg\u00fan estadios patol\u00f3gicos fu\u00e9 en los ta-t2 del 30% y en los t3-t4 fu\u00e9 del 70%, siendo la diferencia estad\u00edsticamente significativa (p 0.0008). Seg\u00fan el grado celular, las mutaciones se encontraron en gl (5,3%), g2 (25%), g3 (75%) siendo estad\u00edsticamente significativas (p 0.00001). La expresi\u00f3n de oncoprote\u00edna p53 en los estadios ta-t2 fu\u00e9 del 23,8% y en los t3-t4 de 31,7% estad\u00edsticamente significativa (p 0.01). La expresi\u00f3n media de oncoprote\u00edna p53 seg\u00fan el grado celular fu\u00e9 de 18,6% en g1, 22,4% en g2 y 33,4% en g3, estad\u00edsticamente significativa (p 0.0001). La relaci\u00f3n entre mutaciones del gen p53 y la expresi\u00f3n media de oncoprote\u00edna es significativa (p 0.00001). Las mutaciones del gen p53 y la expresi\u00f3n del oncoprote\u00edna p53 se correlacionan estad\u00edsticamente con los estadios patol\u00f3gicos avanzados y con un mayor grado de indiferenciaci\u00f3n celular en el carcinoma de c\u00e9lulas transicionales de vejiga.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mutaciones del oncogen supresor p53 en tumores vesicales: correlacion con otros factores pronosticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mutaciones del oncogen supresor p53 en tumores vesicales: correlacion con otros factores pronosticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Ignacio Abad Vivas Perez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/10\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Rosell Costa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Angel Rioja Sanz <\/li>\n<li>Federico Rodriguez Rubio (vocal)<\/li>\n<li>Antonio Brugarolas Masllorens (vocal)<\/li>\n<li>Guillermo L\u00f3pez Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Ignacio Abad Vivas Perez Estudio de las mutaciones del gen p53 y expresi\u00f3n de la oncoprote\u00edna [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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