{"id":33091,"date":"1997-10-10T00:00:00","date_gmt":"1997-10-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-moleculares-implicados-en-la-heterogenidad-funcional-de-la-somatotropa-porcina\/"},"modified":"1997-10-10T00:00:00","modified_gmt":"1997-10-10T00:00:00","slug":"factores-moleculares-implicados-en-la-heterogenidad-funcional-de-la-somatotropa-porcina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/factores-moleculares-implicados-en-la-heterogenidad-funcional-de-la-somatotropa-porcina\/","title":{"rendered":"Factores moleculares implicados en la heterogenidad funcional de la somatotropa porcina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Luis Ram\u00edrez Gutierrez <\/strong><\/h2>\n<p>En la presente tesis doctoral, se ha caracterizado la estimulaci\u00f3n de la secreci\u00f3n de la hormona del crecimiento (gh) ejercida por la somatostatina (srif) sobre dos subpoblaciones de c\u00e9lulas somatotropas porcinas, aisladas por centrifugaci\u00f3n en un gradiente de densidad de percoll. Con dicho estudio se ha demostrado que el srif ejerce un efecto espec\u00edfico y directo sobre las somatotropas de cerdo, actuando como un verdadero estimulador sw la secreci\u00f3n de gh. Este efecto, observado inicialmente en las somatotropas de alta densidad, fue asimismo demostrado en toda la poblaci\u00f3n de somatotropas a dosis muy bajas del p\u00e9ptido, surgiriendo que este factor puede ejercer funciones a trav\u00e9s de distintos subtipos de receptores y\/o prote\u00ednas g acopladas a los mismos.  por otra parte, se han caracterizado las rutas de segundos mensajeros intracelulares implicadas en la estimulaci\u00f3n de la secreci\u00f3n de gh porcina ejercida por la somatostatina y el grf. Se ha confirmado que el grf incrementa la secreci\u00f3n de gh principalmente a trav\u00e9s de la ruta denilato ciclasa-ampc-calcio extracelular en ambas subpoblaciones, con la participaci\u00f3n de la ruta de la plc-fosf\u00e1tidos de inositol-calcio intracelular en las somatotropas de baja densidad. Por su parte, la estimulaci\u00f3n de la secreci\u00f3n de gh ejercida por la somatostatina en ambas subpoblaciones se realiza a trav\u00e9s de mecanismos dependientes de ampc y, aparentemente, independientes de otros segundos mensajeros.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores moleculares implicados en la heterogenidad funcional de la somatotropa porcina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores moleculares implicados en la heterogenidad funcional de la somatotropa porcina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Luis Ram\u00edrez Gutierrez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/10\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Socorro Garcia Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Gracia navarro <\/li>\n<li>justo pastor Casta\u00f1o fuentes (vocal)<\/li>\n<li>gregorio Garc\u00eda herdugo (vocal)<\/li>\n<li>Jes\u00fas a. Fern\u00e1ndez  tresguerres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Luis Ram\u00edrez Gutierrez En la presente tesis doctoral, se ha caracterizado la estimulaci\u00f3n de la secreci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,35,848,973,9399],"tags":[2022,11100,90578,90577,2021,34712],"class_list":["post-33091","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-de-la-vida","category-citologia","category-cordoba","category-cultivo-celular","tag-francisco-gracia-navarro","tag-gregorio-garcia-herdugo","tag-jesus-a-fernandez-tresguerres","tag-jose-luis-ramirez-gutierrez","tag-justo-pastor-castano-fuentes","tag-socorro-garcia-navarro"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33091","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=33091"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33091\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=33091"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=33091"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=33091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}