{"id":33118,"date":"2018-03-09T09:30:06","date_gmt":"2018-03-09T09:30:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sulfato-de-magnesio-como-terapeutica-de-rescate-neural-tras-la-agresion-hipoxico-isquemica-en-un-modelo-porcino-neonatal\/"},"modified":"2018-03-09T09:30:06","modified_gmt":"2018-03-09T09:30:06","slug":"sulfato-de-magnesio-como-terapeutica-de-rescate-neural-tras-la-agresion-hipoxico-isquemica-en-un-modelo-porcino-neonatal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sulfato-de-magnesio-como-terapeutica-de-rescate-neural-tras-la-agresion-hipoxico-isquemica-en-un-modelo-porcino-neonatal\/","title":{"rendered":"Sulfato de magnesio como terapeutica de rescate neural tras la agresion hipoxico-isquemica en un modelo porcino neonatal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Valcarce Lopez <\/strong><\/h2>\n<p>Los mecanismos de da\u00f1o neural que se desencadenan con el evento hip]oxico-isqu\u00e9mico contin\u00faany se amplifican durante el periodo de recuperaci]on. Esta observaci]on ha permitido abrir esperanzas acerca de la posibilidad de bloquear estos mecanismos mediante actuaciones terap\u00e9uticas y por lo tanto prevenir o aminorar el da\u00f1o potencial del snc. Por ello, se esta investigando activamente en nuevas aproximaciones terap\u00e9uticas basadas en los conocimientos actuales sobre los mecanismos patofisiol]ogicos que conducen a la muerte de c\u00e9lulas neurales. En el momento actual no existe ninguna actuaci]on terap\u00e9utica en la practica clinica que prevenga o aminore el da\u00f1o cerebral resultante de un evento hip]oxico-isqu\u00e9mico perinatal, aunque parece ser que la utilizaci]on de mg2+ es la que m\u00e1s fundamentos presenta as\u00ed como la que mejores resultados ha presentado cuando se ha utilizado como una estrategia preventiva o neuroprotectora. El magnesio es una antagonista no competitivo dependiente de voltaje del receptor nmda.  laadministraci]on de bloqueantes espec\u00edficos del receptor de nmda ha mostrado ser una estrategia posible para aminorar el da\u00f1o neuronal en modelos experimentales de da\u00f1o cerebral isqu\u00e9mico, ya que bloquean la principal entrada de ca2+ al interior celular. Por lo tanto, es importante y necesario realizar estudios en los que se utilice esta estrategia terap\u00e9utica de rescate emulando la situaci]on que ocurre en cl\u00ednica.  en este estudio se utilizaron lechones de cinco d\u00edas de edad (n=32) distribuidos en cuatro grupos: control, control+ mgso4, hip]oxico- isqu\u00e9mico, hip]oxico- isqu\u00e9mico+mgso4. Para determinar la eficacia del tratamiento y el da\u00f1oneural se realizaron determinaciones de los niveles de enolasa especifica de neurona en lcr y suero, de los niveles de neuroamino\u00e1cidos en intersticio cerebral utilizando la t\u00e9cnica de microdialisis, y un examen histopatol]ogico de las diferentes estructuras del cerebr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sulfato de magnesio como terapeutica de rescate neural tras la agresion hipoxico-isquemica en un modelo porcino neonatal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sulfato de magnesio como terapeutica de rescate neural tras la agresion hipoxico-isquemica en un modelo porcino neonatal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Valcarce Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/10\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Quero Jim\u00e9nez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Hern\u00e1ndez rodr\u00edguez <\/li>\n<li>enrique Garcia frias (vocal)<\/li>\n<li>carmen Arrabal teran (vocal)<\/li>\n<li>alfonso Macaya (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Valcarce Lopez Los mecanismos de da\u00f1o neural que se desencadenan con el evento hip]oxico-isqu\u00e9mico contin\u00faany se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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