{"id":33139,"date":"2018-03-09T09:30:08","date_gmt":"2018-03-09T09:30:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-respuesta-inmune-celular-frente-al-virus-de-la-fiebre-aftosa-utilizando-virus-recombinantes\/"},"modified":"2018-03-09T09:30:08","modified_gmt":"2018-03-09T09:30:08","slug":"estudio-de-la-respuesta-inmune-celular-frente-al-virus-de-la-fiebre-aftosa-utilizando-virus-recombinantes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-la-respuesta-inmune-celular-frente-al-virus-de-la-fiebre-aftosa-utilizando-virus-recombinantes\/","title":{"rendered":"Estudio de la respuesta inmune celular frente al virus de la fiebre aftosa utilizando virus recombinantes."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Arantza Sanz Parra <\/strong><\/h2>\n<p>La fiebre aftosa (fa) es una de las enfermedades animales m\u00e1s temidas por las p\u00e9rdidas econ\u00f3micas que origina. El agentecausal, el virus de la fiebre aftosa (vfa), es un picornavirus que se compone de una mol\u00e9cula de rna de banda sencilla y polaridad (+) que est\u00e1 rodeada de una capsida icosa\u00e9drica formada por 60 copias de cada una de las 4 prote\u00ednas estructurales del virus: vp1-vp4. En esta tesis hemos analizado la respuesta inmune celular utilizando virus vaccinia y adenovirus recombinantes que expresan las proteinas estructurales del vfa; y para ello hemos inmunizado cobayas, vacas y cerdos con los recombinantes obtenidos. En dichos estudios hemos llegado a las siguientes conclusiones:  1.- Es posible conferir protecci\u00f3n frente a la fa sin inducir respuesta de anticuerpos; 2.- Tanto el virus vaccinia como adenovirus recombinantes que expresan las prote\u00ednas estructurales del vfa son capaces de inducir una respuesta inmune linfoproliferativa espec\u00edfica del vfa. Adem\u00e1s mediante ensayos paralelos a los anteriores se han llegado a las siguientes conclusiones: 1.- El vfa induce una disminuci\u00f3n de la expresi\u00f3n de mol\u00e9culas de clase i en las c\u00e9lulas infectadas; 2.- La prote\u00edna vp1 parece asociarse bien directa o indirectamente a las queratinas de los filamentos intermedios del ciroesqueleto; durante el ciclo infectivo del vfa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la respuesta inmune celular frente al virus de la fiebre aftosa utilizando virus recombinantes.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la respuesta inmune celular frente al virus de la fiebre aftosa utilizando virus recombinantes. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Arantza Sanz Parra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/10\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Victoria Ley Vega De Seoane<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: esteban Domingo solans <\/li>\n<li>margarita Del val latorre (vocal)<\/li>\n<li>Antonio Villaverde corrales (vocal)<\/li>\n<li>eduardo Martinez naves (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arantza Sanz Parra La fiebre aftosa (fa) es una de las enfermedades animales m\u00e1s temidas por las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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