{"id":33155,"date":"2018-03-09T09:30:09","date_gmt":"2018-03-09T09:30:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/trasplante-autologo-de-celulas-progenitoras-hematopoyeticas-en-cancer-de-mama-de-alto-riesgo\/"},"modified":"2018-03-09T09:30:09","modified_gmt":"2018-03-09T09:30:09","slug":"trasplante-autologo-de-celulas-progenitoras-hematopoyeticas-en-cancer-de-mama-de-alto-riesgo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/trasplante-autologo-de-celulas-progenitoras-hematopoyeticas-en-cancer-de-mama-de-alto-riesgo\/","title":{"rendered":"Trasplante autologo de celulas progenitoras hematopoyeticas en cancer de mama de alto riesgo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Escudero Soto <\/strong><\/h2>\n<p>Se analizan 86 casos de cancer de mama de alto riesgo tratados con transplante autologo de celulas progenitoras hematopoyeticas realizados entre mayo 1992 y diciembre 1996.  la toxicidad fue aceptable con solo 3 casos con complicaciones grado iii comprometiendo la vida y una mortalidad toxica de 1,2% en los 100 primeros dias.  aceleraron el injerto leucoplaquetario la utilizacion de progenitores de sangre periferica frente a medula osea y la infusion de una cifra de celulas cd34+ superior a 3x10e6\/kg. Esto se tradujo en una reduccion significativa del numero de concentrados de hematies y plaquetas transfundidos, disminucion del numero de dias con antibioticos y acortamiento de la estancia media hospitalaria en 4 dias.  las cifras estimadas de supervivencia actuarial a 5 a\u00f1os fue para la supervivencia global 73% (ic95%: 50-81%) y 66% (ic95%: 58-74%) para la supervivencia libre de enfermedad, interviniendo negativamente sobre esta ultima la ausencia de receptores hormonales y la afectacion de 20 \u00f3 mas ganglios axilares ipsilaterales en la cirugia.  con una mediana de seguimiento de 2,5 a\u00f1os han recaido 18 de las 86 pacientes de la serie, demostrando el analisis multivariante una probabilidad de recaida de 2,75 (ic95%:  1,63- 4,66) veces superior en las pacientes con receptores hormonales negativos.  durante el periodo del estudio se realizaron en el hospital universitario de la princesa y clinica ruber 446 transplantes autologos, de los cuales 147 (32,2%) fueron por cancer de mama, aumentando el porcentaje de 23,9% en 1992 a 47,7% en 1996.  finalmente los autotransplantes para situaciones de alto riesgo representaban en 1992 23,5% de todos los realizados para cancer de mama, aumentando hasta 74,4% en 1996.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Trasplante autologo de celulas progenitoras hematopoyeticas en cancer de mama de alto riesgo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Trasplante autologo de celulas progenitoras hematopoyeticas en cancer de mama de alto riesgo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Escudero Soto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/10\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 M. Fernandez Ra\u00f1ada Gandara<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Pajares Garc\u00eda <\/li>\n<li>joaqu\u00edn D\u00edaz mediavilla (vocal)<\/li>\n<li>gumersindo Perez manga (vocal)<\/li>\n<li>Carlos Solano bercet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Escudero Soto Se analizan 86 casos de cancer de mama de alto riesgo tratados con transplante [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,218,139],"tags":[54898,90702,9553,9598,90700,90701],"class_list":["post-33155","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-hematologia","category-medicina-interna","tag-antonio-escudero-soto","tag-carlos-solano-bercet","tag-gumersindo-perez-manga","tag-joaquin-diaz-mediavilla","tag-jose-m-fernandez-ranada-gandara","tag-jose-maria-pajares-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=33155"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33155\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=33155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=33155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=33155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}