{"id":33177,"date":"2018-03-09T09:30:11","date_gmt":"2018-03-09T09:30:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-factor-antiperinuclear-en-la-artritis-reumatoide\/"},"modified":"2018-03-09T09:30:11","modified_gmt":"2018-03-09T09:30:11","slug":"el-factor-antiperinuclear-en-la-artritis-reumatoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-factor-antiperinuclear-en-la-artritis-reumatoide\/","title":{"rendered":"El factor antiperinuclear en la artritis reumatoide."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Santiago Mu\u00f1oz Fernandez <\/strong><\/h2>\n<p>El factor antiperinuclear (fap) es un anticuerpo que se detecta por inmunofluorescencia indirecta (ifi) usando como substrato c\u00e9lulas de la mucosa oral de humanos. Si la reacci]on es positiva, se observan unos gr\u00e1nulos fluorescentes en el citoplasma, con tendencia a situarse alrededor del nucleo.Su presencia se asocia al diagn]ostico de artritis reumatoide (ar).  se realiz]o un estudio encaminado a validar la t\u00e9cnica, a estandarizarla, a investigar su rendimiento diagn]ostico y su relaci]on con la actividad inflamatoria, la evoluci]on de la ar y la presencia de otros autoanticuerpos propios de ella (fr, aka, anti-ra33) en pacientes con ar establecida, as\u00ed como a investigar las implicaciones diagn]osticas, pron]osticas e inmunogen\u00e9ticas de la presencia del fap en el suero de pacientes con la artritis de menos de 6 meses de evoluci]on.  tras la estandarizaci]on de la t\u00e9cnica, se estudi]o su rendimiento diagn]ostico en 410 sujetos distribuidos en 4 grupos: ar seropositiva, ar seronegativa, grupo de pacientes con otras enfermedades y de sujetos sanos.  posteriormente se investig]o la asociaci]on del fap con los par\u00e1metros de actividad inflamatoria, capacidad funcional, manifestaciones extrarticulares, \u00edndice radi]ologico y otros autoanticuerpos (fr, aka y anti-ra33) de 103 pacientes con ar establecida seguidos prospectivamente 3 a\u00f1os. Por \u00faltimo, se determin]o el fap en el suero de la primera consulta de 180 pacientes con artritis de menos de 6 meses de evoluci]on, que se siguieron prospectivamente de 1 a 5 a\u00f1os, para investigar su relaci]on con el diagn]ostico, capacidad funcional, persistencia de la actividad y de antigenos hla de clase ii.  se encontr]o el fap con frecuencia significativamente mayor en los pacientes con ar seropositiva (55,7%) y seronegativa (38,9%) que en el grupo control de otras enfermedades (11%) y de sujetos sanos (5,9%), con sensibilidad 50%, especificidad 90,2%, vpp 76,5% y vpn (73, 1%.  e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El factor antiperinuclear en la artritis reumatoide.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El factor antiperinuclear en la artritis reumatoide. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Santiago Mu\u00f1oz Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/10\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Gijon Ba\u00f1os<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gumersindo Fontan casariego <\/li>\n<li>Mar\u00eda angeles Figueredo delgado (vocal)<\/li>\n<li>alejandro Oliv\u00e9 marqu\u00e9s (vocal)<\/li>\n<li>armando Laff\u00f3n roca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Santiago Mu\u00f1oz Fernandez El factor antiperinuclear (fap) es un anticuerpo que se detecta por inmunofluorescencia indirecta (ifi) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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