{"id":33178,"date":"2018-03-09T09:30:11","date_gmt":"2018-03-09T09:30:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-hepatoprotector-de-la-s-adenosilmetionina-en-la-colestasis-por-ltd4-estudio-en-higado-de-rata-aislado-y-perfundido\/"},"modified":"2018-03-09T09:30:11","modified_gmt":"2018-03-09T09:30:11","slug":"efecto-hepatoprotector-de-la-s-adenosilmetionina-en-la-colestasis-por-ltd4-estudio-en-higado-de-rata-aislado-y-perfundido","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-hepatoprotector-de-la-s-adenosilmetionina-en-la-colestasis-por-ltd4-estudio-en-higado-de-rata-aislado-y-perfundido\/","title":{"rendered":"Efecto hepatoprotector de la s-adenosilmetionina en la colestasis por ltd4. estudio en higado de rata aislado y perfundido."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Nicolae Cincu <\/strong><\/h2>\n<p>En el h\u00edgado de rata aislado y perfundido la administraci\u00f3n de 2 nmoles de ltd4 produce los siguientes efectos: 1) reducci\u00f3n del flujo biliar y de la secreci\u00f3n biliar de sales biliares y gsh; 2) aumento de los niveles de got y ldh en el efluente; 3) alteraci\u00f3n de la presi\u00f3n de perfusi\u00f3n; 4) incremento de la peroxidaci\u00f3n lip\u00eddica con disminuci\u00f3n de los niveles de gsh; y 5) reducci\u00f3n de la actividad de la enzima metionina adenosiltransferasa (mat), que cataliza la s\u00edntesis hep\u00e1tica de glutation, con desplazamiento del balance entre las isoformas mat iii\/mat i hacia la forma menos activa (mat iii). La infusi\u00f3n continua de adomet a estos h\u00edgados corrigi\u00f3 pr\u00e1cticamente todos los efectos del ltd4: 1) previno totalmente la ca\u00edda del flujo biliar y de la secreci\u00f3n biliar de sbs, y parcialmente la de la secreci\u00f3n biliar de gsh; 2) redujo los niveles de got y ldh a niveles incluso inferiores a los medidos en el grupo control; 3) corrigi\u00f3 las alteraciones en la presi\u00f3n de perfusi\u00f3n en forma dependiente de dosis; 4) mejor\u00f3 el estado oxidativo de los h\u00edgados recuperando los niveles de gsh y reduciendo la peroxidaci\u00f3n lip\u00eddica; y 5) increment\u00f3 la actividad mat desplazando el equilibrio mat iii\/mat i hacia la forma tetram\u00e9rica (la m\u00e1s activa). Adem\u00e1s, la adomet mejor\u00f3 la captaci\u00f3n hep\u00e1tica y secreci\u00f3n biliar del ltd4, lo cual puede constituir un mecanismo de protecci\u00f3n, al liberar al h\u00edgado de estos metabolitos t\u00f3xicos. Los efectos de la adomet mostraron ser espec\u00edficos, ya que la utilizaci\u00f3n de meitionina en lugar de adomet, s\u00f3lo produjo una mejora parcial del efecto del ltd4.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto hepatoprotector de la s-adenosilmetionina en la colestasis por ltd4. estudio en higado de rata aislado y perfundido.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto hepatoprotector de la s-adenosilmetionina en la colestasis por ltd4. estudio en higado de rata aislado y perfundido. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Nicolae Cincu <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/10\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Manuel Rodr\u00edguez Ortigosa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: natalia Mar\u00eda Lopez moratalia <\/li>\n<li>Jos\u00e9 Mar\u00eda Mato de la paz (vocal)<\/li>\n<li>joan Caballeria rovira (vocal)<\/li>\n<li>Juan  Emilio Feliu albi\u00f1ana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Nicolae Cincu En el h\u00edgado de rata aislado y perfundido la administraci\u00f3n de 2 nmoles de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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