{"id":33297,"date":"2018-03-09T09:30:21","date_gmt":"2018-03-09T09:30:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-ultraestructural-de-la-lesion-inducida-por-el-glutamato-monosodico-en-el-nucleo-arcuato-del-hipotalamo-de-rata\/"},"modified":"2018-03-09T09:30:21","modified_gmt":"2018-03-09T09:30:21","slug":"estudio-ultraestructural-de-la-lesion-inducida-por-el-glutamato-monosodico-en-el-nucleo-arcuato-del-hipotalamo-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-ultraestructural-de-la-lesion-inducida-por-el-glutamato-monosodico-en-el-nucleo-arcuato-del-hipotalamo-de-rata\/","title":{"rendered":"Estudio ultraestructural de la lesion inducida por el glutamato monosodico en el nucleo arcuato del hipotalamo de rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen M. Simon Salvador <\/strong><\/h2>\n<p>Se ha realizado un estudio ultraestructural del territorio del n\u00facleo arcuato de ratas sprague-dawley a las que se administr\u00f3 a los 4 d\u00edas de edad por v\u00eda subcut\u00e1nea 4 mg de glutamato monos\u00f3dico por gramo de peso corporal, siendo sacrificadas 6, 12, 24, 36 horas y 4 d\u00edas despu\u00e9s de la inyecci\u00f3n. Como controles se han utilizado ratas inyectadas con agua bidestilada. En los animales sacrificados seis horas despu\u00e9s de la administraci\u00f3n de glutamato monos\u00f3dico la degeneraci\u00f3n afecta a todas las neuronas del n\u00facleo arcuato del hipot\u00e1lamo, sin que puedan detectarse neuronas intactas.  a partir de las 12 horas del tratamiento neurot\u00f3xico se constata ya la existencia de neuronas normales, cuyo n\u00famero va increment\u00e1ndose progresivamente hasta las 36 horas de supervivencia. En este periodo coexisten neuronas de aspecto normal con las degeneradas cuyo n\u00famero va disminuyendo. La recuperaci\u00f3n comienza en las porciones dorsales del n\u00facleo y se va extendiendo hacia los territorios ventrales. El aspecto ultraestructural del territorio del n\u00facleo arcuato a los 4 d\u00edas de la lesi\u00f3n es similar al que se aprecia en los animales controles y las neuronas de los animales experimentales muestran signos de hiperactividad, entre los que destaca la abundancia de cuerpos gr\u00e1nulo-filamentosos citoplasm\u00e1ticos. S\u00f3lo en los animales sacrificados 6 horas despu\u00e9s de la administraci\u00f3n del agente neurot\u00f3xico se han observado signos de lesi\u00f3n, si bien no severa, en los ependimocitos del territorio del n\u00facleo arcuato, en especial en los del labio dorsal de la prolongaci\u00f3n lateral del receso infundibular. Las im\u00e1genes ultraestructurales de animales sacrificados 6 y 12 horas despu\u00e9s de la administraci\u00f3n de glutamato monos\u00f3dico permiten suponer que algunos ependimocitos participan en la gacocitosis de los restos celulares originados por la lesi\u00f3n. En las ratas tratadas la reacci\u00f3n microglial es patente entre las 6 y las 36 horas, si b<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio ultraestructural de la lesion inducida por el glutamato monosodico en el nucleo arcuato del hipotalamo de rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio ultraestructural de la lesion inducida por el glutamato monosodico en el nucleo arcuato del hipotalamo de rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen M. Simon Salvador <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/11\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Amat Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Rodr\u00edguez Garc\u00eda <\/li>\n<li>isabel San Jos\u00e9 crespo (vocal)<\/li>\n<li>m. belen Pelaez pezzi (vocal)<\/li>\n<li>Mar\u00eda  Elena Garcia  sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen M. Simon Salvador Se ha realizado un estudio ultraestructural del territorio del n\u00facleo arcuato de ratas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,9,515,9386,10090],"tags":[90950,27939,45548,90951,9433,7914],"class_list":["post-33297","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-medicas","category-ciencias-veterinarias","category-salamanca","category-toxicidad-de-los-alimentos","tag-carmen-m-simon-salvador","tag-isabel-san-jose-crespo","tag-m-belen-pelaez-pezzi","tag-maria-elena-garcia-sanchez","tag-pedro-amat-munoz","tag-santiago-rodriguez-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33297","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=33297"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33297\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=33297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=33297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=33297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}