{"id":33328,"date":"2018-03-09T09:30:24","date_gmt":"2018-03-09T09:30:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/terapia-genica-del-carcinoma-epidermoide-de-cabeza-y-cuello-mediante-adenovirus-recombinante\/"},"modified":"2018-03-09T09:30:24","modified_gmt":"2018-03-09T09:30:24","slug":"terapia-genica-del-carcinoma-epidermoide-de-cabeza-y-cuello-mediante-adenovirus-recombinante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/terapia-genica-del-carcinoma-epidermoide-de-cabeza-y-cuello-mediante-adenovirus-recombinante\/","title":{"rendered":"Terapia genica del carcinoma epidermoide de cabeza y cuello mediante adenovirus recombinante."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel Miranda Garcia <\/strong><\/h2>\n<p>En este trabajo se estudia la eficacia de la transducci\u00f3n de un adenovirus suicida en cultivos celulares y tumores s\u00f3lidos (carcinoma epidemoide) y el efecto terap\u00e9utico antitumoral que se obtiene al administrar ganciclovir.  en la primera fase de estudios in vitro se valor\u00f3 el grado de transducci\u00f3n de tres l\u00edneas celulares humanas provenientes de carcinomas epidemoides de cabeza y cuello por el adenovirus recombinante adcmv1acz. Posteriormente se valor\u00f3 la eliminaci\u00f3n tumoral en cultivos celulares despu\u00e9s de ser infectados por el adenovirus suicida adcmvtk y recibir posteriormente tratamiento con ganciclovir.  en la 2a fase o de experimentos in vivo, se utiliz\u00f3 un modelo animal de carcinoma epidemoide de cabeza y cuello utilizando ratones desnudos. Despu\u00e9s de transcurrir 10 d\u00edas de la inyecci\u00f3n subcut\u00e1nea de c\u00e9lulas tumorales se inyect\u00f3 adcmvtk o adcmvlacz, seg\u00fan fuera el grupo tratado o grupo control.  transcurridas 48 horas, se trat\u00f3 con ganciclovir y al 19o d\u00eda se sacrificaron los animales, se extirparon las masas tumorales y se midieron y procesaron histol\u00f3gicamente.  como conclusiones, cabe se\u00f1alar la eficacia del vector utilizado para transducir las c\u00e9lulas tumorales empleadas, as\u00ed como la eficacia del tratamiento con ganciclovir, tanto en cultivos celulares como en el modelo animal utilizado. Asimismo, se determina el m\u00e9todo estereol\u00f3gico de caballieri como m\u00e9todo v\u00e1lido y preciso para valorar la respuesta en los diferentes experimentos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Terapia genica del carcinoma epidermoide de cabeza y cuello mediante adenovirus recombinante.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Terapia genica del carcinoma epidermoide de cabeza y cuello mediante adenovirus recombinante. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel Miranda Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/11\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Garcia Tapia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: torcuato Labella caballero <\/li>\n<li>secundino Fern\u00e1ndez gonz\u00e1lez (vocal)<\/li>\n<li>Jos\u00e9 Vergara trujillo (vocal)<\/li>\n<li>pedro Quesada marin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel Miranda Garcia En este trabajo se estudia la eficacia de la transducci\u00f3n de un adenovirus suicida [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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