{"id":33382,"date":"2018-03-09T09:30:28","date_gmt":"2018-03-09T09:30:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-oxitetraciclina-sobre-la-morfologia-del-higado-de-rata\/"},"modified":"2018-03-09T09:30:28","modified_gmt":"2018-03-09T09:30:28","slug":"efecto-de-la-oxitetraciclina-sobre-la-morfologia-del-higado-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-oxitetraciclina-sobre-la-morfologia-del-higado-de-rata\/","title":{"rendered":"Efecto de la oxitetraciclina sobre la morfolog\u00eda del higado de rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Pastor Mancisidor <\/strong><\/h2>\n<p>Hemos dise\u00f1ado un trabajo experimental con el fin de valorar: a) la capacidad de las tetraciclinas para inducir esteatosis microvesicular en el h\u00edgado de rata administradas durante un periodo de tiempo prolongado, b) valorar si la rata hembra presenta una mayor susceptibilidad a las mismas, c) estudiar las posibles alteraciones ultraestructurales y su relaci\u00f3n con los mecanismos de esteatosis sugeridos. M\u00e9todos: 62 ratas wistar (31 machos y 31 hembras) fueron distribuidas en 6 grupos, 2 grupos controles y 4 grupos experimentales. La duraci\u00f3n del experimento fu\u00e9 de 3 meses, extray\u00e9ndose bajo anestesia muestras de sangre y tejido hep\u00e1tico para estudio morfol\u00f3gico (m.O y m.E.). Resultados: la esteatosis fu\u00e9 de tipo microvesicular con una distribuci\u00f3n preferentemente periportal, detectada fundamentalmente en los grupos tratados siendo el grado de esteatosis en estos significativamente mayor en las hembras (p= 0.004). En el estudio ultraestructural el hallazgo m\u00e1s relevante fu\u00e9 la dilataci\u00f3n microsomal observada en todos los grupos experimentales sin diferencia entre sexos. Conclusiones: la otc produjo esteatosis hep\u00e1tica microvesicular de predominio periportal fundamentalmente en las hembras. Como posible mecanismo de la esteatosis por otc se sugiere una disminuci\u00f3n de la funci\u00f3n mitocondrial, peroxisomal y microsomal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la oxitetraciclina sobre la morfolog\u00eda del higado de rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la oxitetraciclina sobre la morfolog\u00eda del higado de rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Pastor Mancisidor <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/11\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agustin Caro Paton Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00e1ngel Mara\u00f1\u00f3n cabello <\/li>\n<li>Jaime Mendez martin (vocal)<\/li>\n<li>Mar\u00eda  isabel Echevarria  beltran (vocal)<\/li>\n<li>Mar\u00eda  cruz Coca  garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Pastor Mancisidor Hemos dise\u00f1ado un trabajo experimental con el fin de valorar: a) la capacidad de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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