{"id":33390,"date":"2018-03-09T09:30:29","date_gmt":"2018-03-09T09:30:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-las-regiones-reguladoras-en-cis-de-la-expresion-del-locus-de-la-queratina-8-humana-en-ratones-transgenicos\/"},"modified":"2018-03-09T09:30:29","modified_gmt":"2018-03-09T09:30:29","slug":"analisis-de-las-regiones-reguladoras-en-cis-de-la-expresion-del-locus-de-la-queratina-8-humana-en-ratones-transgenicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/analisis-de-las-regiones-reguladoras-en-cis-de-la-expresion-del-locus-de-la-queratina-8-humana-en-ratones-transgenicos\/","title":{"rendered":"Analisis de las regiones reguladoras en cis de la expresion del locus de la queratina 8 humana en ratones transgenicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Felipe Were Eduardo <\/strong><\/h2>\n<p>En este trabajo hemos investigado en ratones transg\u00e9nicos una actividad lcr en el locus del gen de la queratina 8 humana (hk8), que se expresa de forma espec\u00edfica en epitelios sencillos. Los lcr son elementos de control en cis responsables del establecimiento y mantenimiento del estado transcripcionalmente activo de dominios cromos\u00f3micos.  nuestro an\u00e1lisis ha permitido identificar un fragmento gen\u00f3mico del locus hk8, de 34 kb, que contiene una actividad lcr. Hemos determinado adem\u00e1s que las secuencias responsables para esta actividad lcr se localizan en secuencias intrag\u00e9nicas. La organizaci\u00f3n de esta actividad lcr se asemeja a la del lcr asociado al locus del gen de la lisozima de pollo, ya que requiere la participaci\u00f3n de diversos elementos en cis distribuidos en el locus.  tambi\u00e9n hemos determinado que el primer intr\u00f3n contiene elementos de control necesarios para la expresi\u00f3n espec\u00edfica de tejido de hk8, de forma que la deleci\u00f3n de esta regi\u00f3n resulta en p\u00e9rdidas importantes de expresi\u00f3n en tejidos como plexos coroideos, hip\u00f3fisis, intestino o membranas extraembrionarias.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis de las regiones reguladoras en cis de la expresion del locus de la queratina 8 humana en ratones transgenicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis de las regiones reguladoras en cis de la expresion del locus de la queratina 8 humana en ratones transgenicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Felipe Were Eduardo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/11\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Vidal Caballero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Lopez otin <\/li>\n<li>Rafael Garesse (vocal)<\/li>\n<li>Luis Montoliu (vocal)<\/li>\n<li>Javier Rey campos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Felipe Were Eduardo En este trabajo hemos investigado en ratones transg\u00e9nicos una actividad lcr en el locus [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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