{"id":33394,"date":"2018-03-09T09:30:29","date_gmt":"2018-03-09T09:30:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilidad-diagnostica-comparativa-de-siete-marcadores-tumorales-en-pacientes-con-derrame-pleural\/"},"modified":"2018-03-09T09:30:29","modified_gmt":"2018-03-09T09:30:29","slug":"utilidad-diagnostica-comparativa-de-siete-marcadores-tumorales-en-pacientes-con-derrame-pleural","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/utilidad-diagnostica-comparativa-de-siete-marcadores-tumorales-en-pacientes-con-derrame-pleural\/","title":{"rendered":"Utilidad diagnostica comparativa de siete marcadores tumorales en pacientes con derrame pleural."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonia Luisa Espasa Sempere <\/strong><\/h2>\n<p>El diagn\u00f3stico etiol\u00f3gico del derrame pleural, es un problema frecuente en la pr\u00e1ctica cl\u00ednica. La utilidad de los marcadores tumorales para distinguir entre derrames pleurales benignos y malignos, todav\u00eda no est\u00e1 bien definida. Se ha realizado un estudio prospectivo de casos y controles, para evaluar la capacidad diagn\u00f3stica, de forma individual y combinada, de la dosificaci\u00f3n en suero y en l\u00edquido pleural de los marcadores tumorales cea, ca 15.3, ca 125, ca 19.9, ca 50, ca 549 y cyfra 21-1 en pacientes con derrame pleural.  la muestra estudiada consta de 389 pacientes con derrame pleural (133 malignos y 256 benignos: 92 trasudados, 50 paraneum\u00f3nicos, 41 tuberculosis, 23 emplemas, 10 postraum\u00e1ticos, 7 tromboembolismos pulmonares y 33 de otras etiolog\u00edas). La utilidad diagn\u00f3stica de cada marcador tumoral fue establecida mediante curvas cor que nos permiten encontrar el punto de corte \u00f3ptimo, de mayor exactitud diagn\u00f3stica.  los marcadores con mayor capacidad diagn\u00f3stica en l\u00edquido pleural son el ca 549, cea y ca 15.3, que con especificidad superior al 0,98 ofrecen sensibilidades del 0,53, 0,49 y 0,44 respectivamente; obteni\u00e9ndose con el ca 549 la mayor exactitud (0,83), as\u00ed como el mejor valor predictivo positivo (0,96) y negativo (0,80). En el suero, los marcadores m\u00e1s eficaces son el ca 15.3 seguido del ca 549 y del cyfra 21-1, pues para especificidades superiores al 0.97 se obtienen sensibilidades del 0,44, 0,44 y 0,42 respectivamente.  la mejor combinaci\u00f3n de marcadores en l\u00edquido pleural corresponde a la formada por el ca 549 y cea que ofrece un exactitud del 0,87 con una especificidad del 0,96 y una sensibilidad del 0,69. Con igual especificidad, en suero, la mejor combinaci\u00f3n corresponde a ca 15,3 y cyfra 21-1 con una sensibilidad de 0,62.  conclu\u00edmos, que puesto que existe correlaci\u00f3n entre los valores de los marcadores tumorales en l\u00edquido pleural y en suero, su determinaci\u00f3n en am<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilidad diagnostica comparativa de siete marcadores tumorales en pacientes con derrame pleural.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilidad diagnostica comparativa de siete marcadores tumorales en pacientes con derrame pleural. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonia Luisa Espasa Sempere <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/11\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Santiago Romero Candeira<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Merino sanchez <\/li>\n<li>Mar\u00eda  victoria Villena garrido (vocal)<\/li>\n<li>Mar\u00eda  Luisa Graells ferrer (vocal)<\/li>\n<li>isabel Tovar zapata (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonia Luisa Espasa Sempere El diagn\u00f3stico etiol\u00f3gico del derrame pleural, es un problema frecuente en la pr\u00e1ctica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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