{"id":33409,"date":"1997-02-12T00:00:00","date_gmt":"1997-02-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-los-genes-p53-y-p16-cdkn2-y-del-grado-de-ploidia-cromosomica-en-el-diagnostico-y-pronostico-del-tumor-de-vejiga\/"},"modified":"1997-02-12T00:00:00","modified_gmt":"1997-02-12T00:00:00","slug":"implicacion-de-los-genes-p53-y-p16-cdkn2-y-del-grado-de-ploidia-cromosomica-en-el-diagnostico-y-pronostico-del-tumor-de-vejiga","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/implicacion-de-los-genes-p53-y-p16-cdkn2-y-del-grado-de-ploidia-cromosomica-en-el-diagnostico-y-pronostico-del-tumor-de-vejiga\/","title":{"rendered":"Implicacion de los genes p53 y p16 cdkn2 y del grado de ploidia cromosomica en el diagnostico y pronostico del tumor de vejiga."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Angel Preciado Lopez <\/strong><\/h2>\n<p>Se han analizado los genes p53 y p16 cdkn2 en 147 pacientes con tumor de vejiga y el grado de ploid\u00eda cromos\u00f3mica en 75 de esos pacientes. El gen p53 se ha estudiado mediante pcr-sscp y en un subgrupo de 42 pacientes se ha analizado el nivel de expresi\u00f3n de la prote\u00edna p53. El gen p16 cdkn2 tambi\u00e9n se ha estudiado mediante pcr-sscp y adem\u00e1s se ha analizado el estado de metilaci\u00f3n de so promtor. Se ha hecho pcr-sscp m\u00faltiple de los exones 5-9 de p53 en una reacci\u00f3n y en otra la secuencia codificante de p16. Se ha encontrado que las mutaciones de p53 tienen una relaci\u00f3n directa con la progresi\u00f3n tumoral e inversa con el tiempo de recurrencia y supervivencia. Las alteraciones de p53 no aportan mejor pron\u00f3stico que el estadio. Las mutaciones puntuales de p16 no est\u00e1n asociadas con el tumor de vejiga. La metilaci\u00f3n de p16 parece asociarse con un menor tiempo de progresi\u00f3n y de supervivencia. El grado de ploidi\u00eda tiene una implicaci\u00f3n directa con la recurrencia y la progresi\u00f3n tumoral. De los modelos de predicci\u00f3n, s\u00f3lo el que predice los pacientes \u00e9xitus tendr\u00eda utilidad cl\u00ednica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicacion de los genes p53 y p16 cdkn2 y del grado de ploidia cromosomica en el diagnostico y pronostico del tumor de vejiga.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicacion de los genes p53 y p16 cdkn2 y del grado de ploidia cromosomica en el diagnostico y pronostico del tumor de vejiga. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Angel Preciado Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 P\u00fablica de navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/12\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Sira Moreno Laguna<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jos\u00e9 Gonz\u00e1lez aguilera <\/li>\n<li>Mar\u00eda  antonia Ramos arroyo (vocal)<\/li>\n<li>rosa Guarch troyas (vocal)<\/li>\n<li>Miguel Anderiz lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Angel Preciado Lopez Se han analizado los genes p53 y p16 cdkn2 en 147 pacientes con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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