{"id":33440,"date":"1997-05-12T00:00:00","date_gmt":"1997-05-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-las-prostaglandinas-en-un-modelo-de-esofagitis-cronica-inducido-por-acido-y-pepsina\/"},"modified":"1997-05-12T00:00:00","modified_gmt":"1997-05-12T00:00:00","slug":"papel-de-las-prostaglandinas-en-un-modelo-de-esofagitis-cronica-inducido-por-acido-y-pepsina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-las-prostaglandinas-en-un-modelo-de-esofagitis-cronica-inducido-por-acido-y-pepsina\/","title":{"rendered":"Papel de las prostaglandinas en un modelo de esofagitis cronica inducido por acido y pepsina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mercedes Molina Del Rio <\/strong><\/h2>\n<p>Existe controversia acerca del papel de las prostaglandinas en la mucosa esof\u00e1gica, habi\u00e9ndose sugerido que median la lesi\u00f3n inducida por \u00e1cido. Estos datos no han sido corroborados en estudios epidemiol\u00f3gicos en humanos.  objetivo: evaluar el papel de las prostaglandinas en un modelo de esofagitis cr\u00f3nica en el conejo.  m\u00e9todos: se indujo esofagitis mediante la perfusi\u00f3n de pepsina acidificada (45 min\/12 durante 5 d\u00edas) que origina lesiones caracterizadas por p\u00e9rdida epitelial, inflamaci\u00f3n y cambios reactivos epiteliales similares a los del humano (puntuaci\u00f3n de lesi\u00f3n 0-100). En este modelo se evalu\u00f3 la concentraci\u00f3n mucosa de prostaglandina e2 (r.I.A.) Y el efecto de la administraci\u00f3n de indometacina (1 mg\/kg\/12h s.C.), Del inhibidor cox-2 nimesulida (3 mg\/kg\/12h s.C.), misoprostol p.O. (200 ug\/d\u00eda), pge2 (p.O. 20 ug\/12h); pge (s.C. 4ug\/12h). Tambi\u00e9n se evalu\u00f3 la actividad cox-1 y cox-2 in vitro en mucosa estimulada con \u00e1cido araquid\u00f3nico c14 y secreci\u00f3n de pge2- c14 modulada por indometacina e inhibidor selectivo cox-2.  resultados: los niveles de pge2 en la mucosa esof\u00e1gica aumentan con el da\u00f1o mucoso (26,2+-8,2b en esof. Sano vs 227+-64* esofagitis alto grado). La participaci\u00f3n de cox-2 es tambi\u00e9n proporcional al da\u00f1o mucoso pero no supera el 30% de la actividad total (10%-26.6%). La administraci\u00f3n de indometacina, pero no de nimesulida, reduce los niveles mucosos de pge2 aunque no afecta el grado de lesi\u00f3n. La administraci\u00f3n de prostaglandinas, sin embargo previene la lesi\u00f3n mucosa inducida por \u00e1cido y pepsina.  control indo nimesul misop pge2 p.O. Pge2 s.C.  lesi\u00f3n a   47+-7 43+-7 31+-8 25+-3* 12+-0.6* 22+-10* (pge2)b 227+-64 3,5+-1,2* 205+-33 234+-79 434+-96 246+-50  *p&lt;0.05; score; b=conc. En mucosa (pg\/gr tejido) conclusiones: el incremento de prostaglandinas en laesofagitis depende fundamentalmente de la actividad cox-1 y no inducen lesi\u00f3n. Su efecto protector end\u00f3geno pare<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las prostaglandinas en un modelo de esofagitis cronica inducido por acido y pepsina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las prostaglandinas en un modelo de esofagitis cronica inducido por acido y pepsina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mercedes Molina Del Rio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/12\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Lanas Arbeloa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Ortego fernandez de retana <\/li>\n<li>Francisco Javier Jim\u00e9nez p\u00e9rez (vocal)<\/li>\n<li>Fernando Escolar castellon (vocal)<\/li>\n<li>Francisco Esteva d\u00edaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mercedes Molina Del Rio Existe controversia acerca del papel de las prostaglandinas en la mucosa esof\u00e1gica, habi\u00e9ndose [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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