{"id":3351,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/alteraciones-inducidas-por-la-proteina-oncogenica-p21-ras-en-el-metabolismo-glucidico-de-fibroblastos-de-rinon-de-rata\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"alteraciones-inducidas-por-la-proteina-oncogenica-p21-ras-en-el-metabolismo-glucidico-de-fibroblastos-de-rinon-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/alteraciones-inducidas-por-la-proteina-oncogenica-p21-ras-en-el-metabolismo-glucidico-de-fibroblastos-de-rinon-de-rata\/","title":{"rendered":"Alteraciones inducidas por la proteina oncogenica p21-ras en el metabolismo glucidico de fibroblastos de ri\u00f1on de rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Onetti Sanchez <\/strong><\/h2>\n<p>La transformacion celular de celulas kimusv-nrk por el oncogen k-ras origina un aumento en la glucolisis, aumentando los flujos por hk y pfk-1, la produccion de lactato y el consumo de glucosa. El aumento en el flujo por pfk-1 es consecuencia, al menos en parte, de una mayor concentracion de fructosa 2,6-bisfosfato como resultado de una mayor actividad pfk-2. Esta mayor actividad pfk-2 es consecuencia de una mayor concentracion del enzima, si bien no se descartan otros mecanismos adicionales. Ademas, la expresion del oncogen k-ras conduce a un aumento en la captacion de 2-dog sin aumentar paralelamente el numero de moleculas de glut-1, pero observandose un aumento en la n-glucosilacion de este transportador, pudiendose traducir esto en cambios cineticos.  la dexametasona e isoprenalina se comportan en estas celulas como agentes glucoliticos, incrementando ambos la concentracion de fructosa 2,6-bisfosfato, actividad pfk-2 y flujos por hk y pfk-1, si bien la dexametasona origina una disminucion en la captacion de 2-dog mientras que la isoprenalina origina un aumento en esta captacion.  ademas, se ha observado una interaccion entre los mecanismos de accion de la dexametasona e isoprenalina y lo utilizados por p21-ras; que no necesita ampc, ca ni pk-c para ejercer sus efectos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones inducidas por la proteina oncogenica p21-ras en el metabolismo glucidico de fibroblastos de ri\u00f1on de rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones inducidas por la proteina oncogenica p21-ras en el metabolismo glucidico de fibroblastos de ri\u00f1on de rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Onetti Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Anna Mar\u00eda Bassols Teixido<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: N\u00e9stor (secretario) G\u00f3mez Trias <\/li>\n<li>Joan Guinovart Cirera (vocal)<\/li>\n<li>Fatima Bosch Tubert (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Onetti Sanchez La transformacion celular de celulas kimusv-nrk por el oncogen k-ras origina un aumento en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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