{"id":33515,"date":"2018-03-09T09:30:40","date_gmt":"2018-03-09T09:30:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-existencia-de-hipogonadismo-en-la-cirrosis-hepatica-avanzada\/"},"modified":"2018-03-09T09:30:40","modified_gmt":"2018-03-09T09:30:40","slug":"estudio-de-la-existencia-de-hipogonadismo-en-la-cirrosis-hepatica-avanzada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-existencia-de-hipogonadismo-en-la-cirrosis-hepatica-avanzada\/","title":{"rendered":"Estudio de la existencia de hipogonadismo en la cirrosis hepatica avanzada."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nieves Diez Go\u00f1i <\/strong><\/h2>\n<p>La cirrosis hep\u00e1tica avanzada (ch) se asocia frecuentemente con hipogonadismo. Por otra parte, en la ch avanzada existe un d\u00e9ficit de igf-i, capaz de estimular la s\u00edntesis de testosterona y la espermatog\u00e9nesis. Se plante\u00f3 la hip\u00f3tesis de que la deficiente s\u00edntesis de igf-i en la ch avanzada podr\u00eda jugar un papel causal en el establecimiento del hipogonadismo. Los objetivos de este trabajo fueron:  comprobar la existencia de hipogonadismo en la ch experimental y evaluar el efecto del tratamiento con igf-i. Se estudiaron los siguientes grupos experimentales: co, grupo de controles sanos (n=10); ci, grupo de ratas cirr\u00f3ticas que recibieron placebo (n=10); y ci+igf, grupo de ratas cirr\u00f3ticas que fueron tratadas con 2 g de igf-i\/100g de pc\/d\u00eda durante 21 d\u00edas (protocolo i). Posteriormente se analizaron los mismos par\u00e1metros en estad\u00edos precoces de la hepatopat\u00eda, para establecer -en lo posible- la cronolog\u00eda de las lesiones (n=12 por grupo)(protocolo ii). Los animales se estudiaron a las 27 semanas (protocolo i: estad\u00edo avanzado, con ascitis) y a las 15 semanas (protocolo ii:  estad\u00edo precoz de la cirrosis). En el protocolo i: con respecto al grupo co, se encontr\u00f3 una disminuci\u00f3n marcada y significativa del peso y tama\u00f1o testicular en el grupo ci y una recuperaci\u00f3n total en el grupo ci+igf. La histolog\u00eda puso de manifiesto una grave (50%) de los animales o notable (30%) atrofia testicular, con desaparici\u00f3n de la barrera hematotesticular, p\u00e9rdida de la l\u00ednea germinal y ausencia o importante disminuci\u00f3n de la espermatog\u00e9nesis. Sin embargo, pudo verificarse una recuperaci\u00f3n total o parcial en todos los animales tratados con igf-i. La presencia de pcna (ant\u00edgeno nuclear de proliferaci\u00f3n celular) disminuy\u00f3 significativamente en el grupo ci y fu\u00e9 similar en los animales co y ci+igf. Se encontraron concentraciones elevadas de mda en los dos grupos de animales cirr\u00f3ticos con respecto a los co. Se encontr\u00f3 u<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la existencia de hipogonadismo en la cirrosis hepatica avanzada.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la existencia de hipogonadismo en la cirrosis hepatica avanzada. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nieves Diez Go\u00f1i <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Inmaculada Castilla Cortazar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Berian polo <\/li>\n<li>Jorge  augusto Quiroga vilas (vocal)<\/li>\n<li>Juan  Javier Zudaire bergera (vocal)<\/li>\n<li>Luis Santamar\u00eda solis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nieves Diez Go\u00f1i La cirrosis hep\u00e1tica avanzada (ch) se asocia frecuentemente con hipogonadismo. Por otra parte, en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,17749,384],"tags":[13077,18372,91350,69603,14596,91349],"class_list":["post-33515","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-navarra","category-patologia-clinica","tag-inmaculada-castilla-cortazar","tag-jorge-augusto-quiroga-vilas","tag-jose-maria-berian-polo","tag-juan-javier-zudaire-bergera","tag-luis-santamaria-solis","tag-nieves-diez-goni"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=33515"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33515\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=33515"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=33515"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=33515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}