{"id":33516,"date":"2018-03-09T09:30:40","date_gmt":"2018-03-09T09:30:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/repercusion-de-la-administracion-cronica-de-midazolam-en-el-complejo-basal-magnocelular-de-la-rata\/"},"modified":"2018-03-09T09:30:40","modified_gmt":"2018-03-09T09:30:40","slug":"repercusion-de-la-administracion-cronica-de-midazolam-en-el-complejo-basal-magnocelular-de-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/repercusion-de-la-administracion-cronica-de-midazolam-en-el-complejo-basal-magnocelular-de-la-rata\/","title":{"rendered":"Repercusion de la administracion cronica de midazolam en el complejo basal magnocelular de la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gregorio Marco Naya <\/strong><\/h2>\n<p>El midazolam es la benzodiacepina m\u00e1s vers\u00e1til y una de las m\u00e1s empleadas. El n\u00facleo basal de meynert es la porci\u00f3n mayor y m\u00e1s destacable del complejo basal magnocelular; habi\u00e9ndose relacionado con fen\u00f3menos cognoscitivos, termorreguladores y activaci\u00f3n de la vigilia. Se ha comprobado su afectaci\u00f3n temprana en procesos neurodegenerativos, envejecimiento y toxicidad farmacol\u00f3gica. Empleamos 100 machos de rata wistar, 50 de 6 semanas y 50 de 24 meses, que dividimos en 6 grupos: 2 controles (uno de 6 semanas y el otro de 24 meses) con 10 animales que recibieron clna 0,9% oral durante 120 d\u00edas, 2 de 20 ratas que recibieron 1mg\/kg\/d\u00eda de midazolam durante igual tiempo, y otros dos tambi\u00e9n de 20 que recibieron 3mg\/kg. Analizamos mortalidad, evoluci\u00f3n ponderal, comportamiento, par\u00e1metros morfom\u00e9tricos (recuento neuronal, cario y citometr\u00eda) y datos inmunocitoqu\u00edmicos (t\u00e9cnicas de parvalb\u00famina, ache y chat). Nuestros resultados muestran como el midazolam a\u00fan a dosis superiores a las utilizadas en cl\u00ednica, produce muy escasas modificaciones en el n\u00facleo basal de meynert tanto en ratas j\u00f3venes como en viejas. Estas modificaciones afectan principalmente a la subdivisi\u00f3n intermedia del n\u00facleo, donde se observa mayor p\u00e9rdida neuronal y aumento de la cario\/citometr\u00eda de las ratas que recibieron el f\u00e1rmaco.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Repercusion de la administracion cronica de midazolam en el complejo basal magnocelular de la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Repercusion de la administracion cronica de midazolam en el complejo basal magnocelular de la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gregorio Marco Naya <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Mar\u00eda Gonzalo Sanz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel angel Nalda felipe <\/li>\n<li>Jes\u00fas Honorato perez (vocal)<\/li>\n<li>Juli\u00e1n \u00e1lvarez escudero (vocal)<\/li>\n<li>Jos\u00e9 Luis Arroyo carreras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gregorio Marco Naya El midazolam es la benzodiacepina m\u00e1s vers\u00e1til y una de las m\u00e1s empleadas. El [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,957,17749,156],"tags":[91351,17752,91353,2775,91352,1093],"class_list":["post-33516","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-navarra","category-patologia","tag-gregorio-marco-naya","tag-jesus-honorato-perez","tag-jose-luis-arroyo-carreras","tag-julian-alvarez-escudero","tag-luis-maria-gonzalo-sanz","tag-miguel-angel-nalda-felipe"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33516","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=33516"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33516\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=33516"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=33516"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=33516"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}