{"id":33526,"date":"2018-03-09T09:30:41","date_gmt":"2018-03-09T09:30:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-la-ribonucleoproteina-heterogenea-nuclear-a1-como-un-nuevo-substrato-especifico-de-la-proteina-quinasa-c-zeta\/"},"modified":"2018-03-09T09:30:41","modified_gmt":"2018-03-09T09:30:41","slug":"identificacion-de-la-ribonucleoproteina-heterogenea-nuclear-a1-como-un-nuevo-substrato-especifico-de-la-proteina-quinasa-c-zeta","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/identificacion-de-la-ribonucleoproteina-heterogenea-nuclear-a1-como-un-nuevo-substrato-especifico-de-la-proteina-quinasa-c-zeta\/","title":{"rendered":"Identificacion de la ribonucleoproteina heterogenea nuclear a1 como un nuevo substrato especifico de la proteina quinasa c zeta."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Lozano Castro <\/strong><\/h2>\n<p>Mediante el sistema de dos hibridos en levadura se ha identificado a la proteina hnrnp a1 como un nuevo substrato especifico y directo de la zetapkc. Esta quinasa fosforila a la hnrnp a1 in vitro y media su fosforilacion in vivo con importantes consecuencias sobre su afinidad por los acidos nucleicos y su capacidad de sufrir transporte nucleocitoplasmatico. Esta ultima propiedad ha resultado ser muy sensible a los estimulos de estres genotoxico, los cuales provocan su acumulacion citosolica y variaciones en su estado de fosforilacion.  hemos identificado la ruta de p38 como una de las mediadoras del proceso aunque deben existir otras aun por identificar que participan en el proceso. La simple activacion de p38 por su activador mkk3\/6 es suficiente para provocar su acumulaciocitosolica y su fosforilacion.  tambien se ha estudiado la regulacion enzimatica de zetapkc por las moleculas lipidicas ceramida y esfingosina utilizando comosubstrato en los ensayos in vitro la nueva proteina clonada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificacion de la ribonucleoproteina heterogenea nuclear a1 como un nuevo substrato especifico de la proteina quinasa c zeta.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificacion de la ribonucleoproteina heterogenea nuclear a1 como un nuevo substrato especifico de la proteina quinasa c zeta. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Lozano Castro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Moscat Guill\u00e9n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cecilio Gimenez martin <\/li>\n<li>francisca Mar\u00eda Sanchez jimenez (vocal)<\/li>\n<li>Juan Saus mas (vocal)<\/li>\n<li>Francisco Lozano soto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Lozano Castro Mediante el sistema de dos hibridos en levadura se ha identificado a la proteina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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