{"id":33530,"date":"2018-03-09T09:30:42","date_gmt":"2018-03-09T09:30:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-sintesis-y-evaluacion-biologica-de-nuevas-quinoxalinas-como-agentes-anticancerosos-y-antituberculosos\/"},"modified":"2018-03-09T09:30:42","modified_gmt":"2018-03-09T09:30:42","slug":"diseno-sintesis-y-evaluacion-biologica-de-nuevas-quinoxalinas-como-agentes-anticancerosos-y-antituberculosos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/diseno-sintesis-y-evaluacion-biologica-de-nuevas-quinoxalinas-como-agentes-anticancerosos-y-antituberculosos\/","title":{"rendered":"Dise\u00f1o, sintesis y evaluacion biologica de nuevas quinoxalinas como agentes anticancerosos y antituberculosos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Montoya Alfaro <\/strong><\/h2>\n<p>El descubrimiento de los inhibidores de prote\u00ednas quinasas dependientes (cdki) responsables del control del complejo ciclina-quinasa ciclina dependiente (cdk); familias de prote\u00ednas que dirigen el ciclo celular, ha planteado una nueva l\u00ednea de trabajo que consiste en el desarrollo de compuestos de s\u00edntesis de actividad an\u00e1loga capaces de interrumpir la coordinaci\u00f3n del ciclo celular.  el heterociclo formado por la fusi\u00f3n del anillo de quinoxalina y el anillo de pirazol permite una aproximaci\u00f3n a la estructura de los an\u00e1logos de purinas con actividad inhibidora de quinasas ciclina dependientes. Por otro lado la actividad antibacteriana de la quinoxalinas sugiere que al ser diversamente sustituida puede presentar actividad antituberculosa.  se dise\u00f1an y sintetizan nuevas quinoxalinas sustituidas en posici\u00f3n \u00ab2\u00bb, \u00ab3\u00bb, \u00ab6\u00bb y \u00ab7\u00bb observando actividad antituberculosa en derivados sustituidos en \u00ab2\u00bb y \u00ab3\u00bb. La sustituci\u00f3n con nitrofenilpiperazina en la posici\u00f3n \u00ab3\u00bb, confiere actividad selectiva en leucemia. Asimismo se han sintetizado productos derivados del anillo pirazolo(3,4-b)quinoxalina sustituidos en \u00ab1\u00bb, \u00ab3\u00bb, \u00ab6\u00bb y \u00ab7\u00bb que presentan actividad antitumoral.  la evaluaci\u00f3n biol\u00f3gica como agentes anticancerosos se realiza mediante la valoraci\u00f3n de citotoxicidad seg\u00fan el ensayo de mtt en dos l\u00edneas celulares, evaluaci\u00f3n en 60 l\u00edneas celulares cancerosas humanas y como inhibidores de cdk (pendiente de resultados). Como agentes antituberculosos se eval\u00faan midiendo la capacidad, de los compuestos sintetizados, de inhibir el crecimiento del mycobacterium tuberculosis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, sintesis y evaluacion biologica de nuevas quinoxalinas como agentes anticancerosos y antituberculosos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, sintesis y evaluacion biologica de nuevas quinoxalinas como agentes anticancerosos y antituberculosos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Montoya Alfaro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Monge Vega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felipe Alcudia gonzalez <\/li>\n<li>Miguel Sanchez gonzalez (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Gonzalez de la riva lamana (vocal)<\/li>\n<li>ignacio Aldana moraza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Montoya Alfaro El descubrimiento de los inhibidores de prote\u00ednas quinasas dependientes (cdki) responsables del control del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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