{"id":33571,"date":"2018-03-09T09:30:45","date_gmt":"2018-03-09T09:30:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/brucelosis-experimental-en-ratones-control-de-calidad-de-vacunas-y-estudio-de-factores-de-virulencia\/"},"modified":"2018-03-09T09:30:45","modified_gmt":"2018-03-09T09:30:45","slug":"brucelosis-experimental-en-ratones-control-de-calidad-de-vacunas-y-estudio-de-factores-de-virulencia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/brucelosis-experimental-en-ratones-control-de-calidad-de-vacunas-y-estudio-de-factores-de-virulencia\/","title":{"rendered":"Brucelosis experimental en ratones: control de calidad de vacunas y estudio de factores de virulencia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Jes\u00fas Grillo Dolset <\/strong><\/h2>\n<p>En la primera parte del presente trabajo hemos analizado la calidad de 18 vacunas brucella melitensis rev 1 y brucella abortus b19 producidas en nuestro pa\u00eds, utilizando tanto los criterios microbiol\u00f3gicos habituales como el modelo murino de referencia. Todas las vacunas analizadas (excepto una b19 conteniendo un bajo n\u00famero de bacterias viables) cumpl\u00edan con las caracter\u00edsticas microbiol\u00f3gicas de la legislaci\u00f3n espa\u00f1ola, pero tres vacunas rev 1 y una vacuna b19 pose\u00edan una actividad biol\u00f3gica deficiente en el modelo murino de referencia.  la interpretaci\u00f3n estad\u00edstica de los resultados obtenidos en este modelo biol\u00f3gico est\u00e1 basada en procedimientos gr\u00e1fico-num\u00e9ricos que presentan inconvenientes de orden pr\u00e1ctico y no permiten establecer la existencia de una relaci\u00f3n directa entre virulencia residual e inmunogenicidad en todos los casos que se analizan. Por ello, hemos utilizado procedimientos inform\u00e1ticos m\u00e1s actuales para la determinaci\u00f3n de ambos par\u00e1metros. Una modelizaci\u00f3n probit usada para determinar la virulencia residual mostr\u00f3 resultados muy similares a los obtenidos con el procedimiento gr\u00e1fico de referencia, pero simplific\u00f3 su determinaci\u00f3n. Sin embargo, cuando la comparaci\u00f3n de los valores de inmunogenicidad se realiz\u00f3 mediante una t de student se obtuvieron resultados diferentes a los del procedimiento gr\u00e1fico de referencia.  con estos procedimientos estad\u00edsticos alternativos, cuatro de las vacunas rev 1 analizadas pose\u00edan una calidad biol\u00f3gica deficiente. Adem\u00e1s, la utilizaci\u00f3n de estos procedimientos estad\u00edsticos alternativos puso en evidencia la existencia de una relaci\u00f3n directa entre la p\u00e9rdida de virulencia residual y la p\u00e9rdida de inmunogenicidad de las vacunas. Independientemente de los procedimientos estad\u00edsticos utilizados, el estudio realizado ha demostrado la existencia de una relaci\u00f3n directa entre determinados par\u00e1metros microbiol\u00f3gicos y alteraciones en las p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Brucelosis experimental en ratones: control de calidad de vacunas y estudio de factores de virulencia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Brucelosis experimental en ratones: control de calidad de vacunas y estudio de factores de virulencia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Jes\u00fas Grillo Dolset <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Blasco Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ignacio Moriyon uria <\/li>\n<li>edgardo Moreno (vocal)<\/li>\n<li>Jes\u00fas Aguero baldin (vocal)<\/li>\n<li>clara Mar\u00eda Mar\u00edn alcala (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jes\u00fas Grillo Dolset En la primera parte del presente trabajo hemos analizado la calidad de 18 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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