{"id":33574,"date":"2018-03-09T09:30:45","date_gmt":"2018-03-09T09:30:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-de-los-genes-de-la-il-alfa-y-beta-y-hla-dqa1-en-a-ulcera-peptica\/"},"modified":"2018-03-09T09:30:45","modified_gmt":"2018-03-09T09:30:45","slug":"polimorfismos-de-los-genes-de-la-il-alfa-y-beta-y-hla-dqa1-en-a-ulcera-peptica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismos-de-los-genes-de-la-il-alfa-y-beta-y-hla-dqa1-en-a-ulcera-peptica\/","title":{"rendered":"Polimorfismos de los genes de la il alfa y beta y hla-dqa1 en a ulcera peptica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Santos Santolaria Piedrafita <\/strong><\/h2>\n<p>Helicobacter y pylori y el consumo de aines son los dos factores etiopatog\u00e9nicos m\u00e1s importantes en la \u00falcera p\u00e9ptica (up), sin embargo s\u00f3lamente una peque\u00f1a proporci\u00f3n de pacientes con estos factores desarrollan la enfermedad. La interacci\u00f3n entre factores ambientales y factores propios del individuo podr\u00edan influir en el resultado final. La interleuquina 1beta (il-1beta) y el factor de necrosis tumoral (tnf) alfa son citoquinas que participan en la respuesta inflamatoria desencadenada por h.Pylori y los aines y que adem\u00e1s han demostrado tener un papel importante en la regulaci\u00f3n de procesos biol\u00f3gicos de la mucosa g\u00e1strica. Factores gen\u00e9ticos del huesped, como polimorfismos en los genes de estas citoquinas, podr\u00edan tener un papel importante en la patog\u00e9nesis de la \u00falcera p\u00e9ptica. Objetivo: determinar el genotipo y la frecuencia al\u00e9lica de los polimorfismos de los genes de la interleuquina 1beta (1l-1beta), interleuquina 1ra (il-1ra), tnf alfa y beta y hla-dqa1 en una poblaci\u00f3n de pacientes con \u00falcera p\u00e9ptida y en controles sanos.  m\u00e9todos: se han incluido 210 pacientes con up (151 con \u00falcera duodenal -ud y 59 con \u00falcera g\u00e1strica -ug) y 104 controles sanos. El estudio de los polimorfismos gen\u00e9ticos se ha realizado mediante pcr (reacci\u00f3n en cadena de la polimerasa) a partir de adn\u00ed\u00b0 obtenido de leucocitos de sangre perif\u00e9rica.  resultados: los alelos de los polimorfismos de la il-1beta e il-1ra se distribuyen de forma similar en la up y controles, sin embargo en la \u00falcera duodenal hemos observado como los no portadores del alelo 2 de la il-1b eran m\u00e1s a menudo portadores del alelo 2 de la il-1betas m\u00e1s a menudo no del alelo 2 de la il-1b m\u00e1s a menudo no portadores del alelo 2 de la il-1ra (p&lt;0,001 or=3,6).  este desequilibrio de ligamento existe tambi\u00e9n en la ud asociada a h.Pylori (p&lt;0,01) y no se aprecia ni en la ug ni en la poblaci\u00f3n control. Los alelos de los polimorfismos de la posic<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos de los genes de la il alfa y beta y hla-dqa1 en a ulcera peptica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos de los genes de la il alfa y beta y hla-dqa1 en a ulcera peptica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Santos Santolaria Piedrafita <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Sainz Samitier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: blanca Conde guerri <\/li>\n<li>feliciano Jes\u00fas Ramos fuentes (vocal)<\/li>\n<li>Francisco Esteva d\u00edaz (vocal)<\/li>\n<li>Javier Menarguez palanca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Santos Santolaria Piedrafita Helicobacter y pylori y el consumo de aines son los dos factores etiopatog\u00e9nicos m\u00e1s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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