{"id":33611,"date":"2018-03-09T09:30:49","date_gmt":"2018-03-09T09:30:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/perfil-farmacocinetico-del-temacepam-en-rata-tras-administracion-intravenosa-oral-y-nasal-modelo-farmacocinetico-farmacodinamico-tras-administracion-intravenosa\/"},"modified":"2018-03-09T09:30:49","modified_gmt":"2018-03-09T09:30:49","slug":"perfil-farmacocinetico-del-temacepam-en-rata-tras-administracion-intravenosa-oral-y-nasal-modelo-farmacocinetico-farmacodinamico-tras-administracion-intravenosa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/perfil-farmacocinetico-del-temacepam-en-rata-tras-administracion-intravenosa-oral-y-nasal-modelo-farmacocinetico-farmacodinamico-tras-administracion-intravenosa\/","title":{"rendered":"Perfil farmacocinetico del temacepam en rata tras administracion intravenosa, oral y nasal. modelo farmacocinetico-farmacodinamico tras administracion intravenosa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Escoriaza Jimenez <\/strong><\/h2>\n<p>Introducci\u00f3n. En este trabajo se ha evaluado el comportamiento farmacocin\u00e9tico (fe) del temacepam (tz) tras su administraci\u00f3n i.V., Oral y nasal. Adem\u00e1s, se ha estimado el efecto anticonvulsivante del f\u00e1rmaco, como la inhibici\u00f3n de convulsiones inducidas por pentilentetrazol (ptz), para reflejar las propiedades farmacodin\u00e1micas del tz \u00abin vivo\u00bb. M\u00e9todos. Estudio fc. A tres grupos de ratas wistar se administraron dosis \u00fanicas de 30, 60 y 6 mg\/kg por las v\u00edas intravenosa r\u00e1pida, oral e intranasal, respectivamente. Se recogieron muestras de sangre a distintos tiempos para efectuar la determinaci\u00f3n de las concentraciones de tz en plasma (cp) por medio de un sensible m\u00e9todo de cg. Los perfiles cp frente al tiempo y los par\u00e1metros fc fueron, respectivamente, descritos y calculados usando modelos compartimentales. Estudio fd.  en otro grupo de animales se midi\u00f3 el efecto como el cociente de la dosis umbral convulsivante de ptz tras el tratamiento con tz y la dosis umbral pre-tratamiento; las relaciones entre efecto y cp se describieron usando el modelo de emax. Resultados. Estudio fc. El valor del par\u00e1metro cl calculado tras la administraci\u00f3n por las tres v\u00edas, fue de (media + cv): 2,78 l\/kg+-4,2. Estudio fd. No se observ\u00f3 hist\u00e9resis en la gr\u00e1fica efecto-cp, por lo que las cp pueden emplearse para predecir el efecto.  los estimados de los par\u00e1metros emax y c50 fueron (estimado+-cv), respectivamente: 10,18+5,9 y 1,88 g\/ml+-20,7. Discusi\u00f3n. Estudio fc. Seg\u00fan nuestros resultados, la cin\u00e9tica del tz no se ve afectada por la v\u00eda de administraci\u00f3n. Estudio fd. El m\u00e9todo de evaluaci\u00f3n del efecto anticonvulsivante se ha mostrado adecuado para reflejar las propiedades fd del tz \u00abin vivo\u00bb.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Perfil farmacocinetico del temacepam en rata tras administracion intravenosa, oral y nasal. modelo farmacocinetico-farmacodinamico tras administracion intravenosa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Perfil farmacocinetico del temacepam en rata tras administracion intravenosa, oral y nasal. modelo farmacocinetico-farmacodinamico tras administracion intravenosa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Escoriaza Jimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Carmen Dios Vi\u00e9itez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: edurne Cenarruzabeitia sagarminaga <\/li>\n<li>rosario Calvo duo (vocal)<\/li>\n<li>Manuel j Barbanoj rodr\u00edguez (vocal)<\/li>\n<li>joaquin Giraldez deiro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Escoriaza Jimenez Introducci\u00f3n. En este trabajo se ha evaluado el comportamiento farmacocin\u00e9tico (fe) del temacepam (tz) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[339,9,189,957,17749],"tags":[17998,91539,17947,14229,51408,3586],"class_list":["post-33611","post","type-post","status-publish","format-standard","hentry","category-analisis-de-farmacos","category-ciencias-medicas","category-farmacodinamia","category-farmacologia","category-navarra","tag-edurne-cenarruzabeitia-sagarminaga","tag-javier-escoriaza-jimenez","tag-joaquin-giraldez-deiro","tag-manuel-j-barbanoj-rodriguez","tag-maria-del-carmen-dios-vieitez","tag-rosario-calvo-duo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33611","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=33611"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33611\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=33611"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=33611"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=33611"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}