{"id":33616,"date":"2018-03-09T09:30:50","date_gmt":"2018-03-09T09:30:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-tolerancia-a-morfina-en-ratas-estudio-de-la-relacion-farmacocinetica-farmacodinamia\/"},"modified":"2018-03-09T09:30:50","modified_gmt":"2018-03-09T09:30:50","slug":"desarrollo-de-tolerancia-a-morfina-en-ratas-estudio-de-la-relacion-farmacocinetica-farmacodinamia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-de-tolerancia-a-morfina-en-ratas-estudio-de-la-relacion-farmacocinetica-farmacodinamia\/","title":{"rendered":"Desarrollo de tolerancia a morfina en ratas. estudio de la relacion farmacocinetica-farmacodinamia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Magdalena Mas Nieto <\/strong><\/h2>\n<p>En diferentes cepas de ratas (sprague dawley y wistar), se ha estudiado la evoluci\u00f3n del efecto analg\u00e9sico (test tail-flick) de morfina durante tratamiento continuado; se han analizado las concentraciones plasm\u00e1ticas de morfina y sus metabolitos (hplc) tras la administraci\u00f3n de dosis \u00fanica de morfina y tratamiento continuado; se han calculado los par\u00e1metros farmacocin\u00e9ticos (topfit) para valorar su implicaci\u00f3n en el desarrollo de tolerancia; y se han evaluado la relaci\u00f3n entre concentraciones plasm\u00e1ticas y efecto analg\u00e9sico. Se han observado diferencias farmacodin\u00e1micas intercepa, pero no se debe a peculiaridades farmacocin\u00e9ticas. Existe una buena relaci\u00f3n entre concentraciones plasm\u00e1ticas y efecto intracepa. La morfina parece acumularse de modo eficaz en un subcompartimiento central, probablemente en el intestinal, lo que modula de modo determinante el perfil farmacocin\u00e9tico de morfina en ratas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de tolerancia a morfina en ratas. estudio de la relacion farmacocinetica-farmacodinamia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de tolerancia a morfina en ratas. estudio de la relacion farmacocinetica-farmacodinamia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Magdalena Mas Nieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/1997<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Francisco Horga De La Parte<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Belmonte mart\u00ednez <\/li>\n<li>Juan  Antonio Armijo simon (vocal)<\/li>\n<li>Rafael Maldonado l\u00f3pez (vocal)<\/li>\n<li>Fernando Miralles pardo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Magdalena Mas Nieto En diferentes cepas de ratas (sprague dawley y wistar), se ha estudiado la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,957,6530,37169],"tags":[8829,19393,27438,10699,91546,50511],"class_list":["post-33616","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-farmacologia","category-farmacologia-experimental","category-miguel-hernandez-de-elche","tag-carlos-belmonte-Martinez","tag-fernando-miralles-pardo","tag-jose-francisco-horga-de-la-parte","tag-juan-antonio-armijo-simon","tag-m-magdalena-mas-nieto","tag-rafael-maldonado-lopez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=33616"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33616\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=33616"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=33616"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=33616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}