{"id":33648,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacogenetica-del-metabolismo-de-tioridazina-en-pacientes-psiquiatricos\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"farmacogenetica-del-metabolismo-de-tioridazina-en-pacientes-psiquiatricos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacogenetica-del-metabolismo-de-tioridazina-en-pacientes-psiquiatricos\/","title":{"rendered":"Farmacogenetica del metabolismo de tioridazina en pacientes psiquiatricos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rubia Martinez Alfredo De La <\/strong><\/h2>\n<p>Tioridazina es un f\u00e1rmaco para el que se ha demostrado polimorfismo gen\u00e9tico. Existen diferencias en la eliminaci\u00f3n entre metabolizadores lentos y r\u00e1pidos de debrisoquina (cyp2d6). Con el objetivo de estudiar las implicaciones cl\u00ednicas de este polimorfismo, se ha determinado el fenotipo de debrisoquina en 65 pacientes tratados en monoterapia con tioridazina, y en una poblaci\u00f3n de 336 voluntarios sanos. Tioridazina se ha comportado como un inhibidor dosis-dependiente del cyp2d6. El \u00edndice metab\u00f3lico de debrisoquina y el ratio meso\/tioridazina (ambos correlacionados) podr\u00edan ser un condicionante de los niveles plasm\u00e1ticos del f\u00e1rmaco y sus metabolitos, as\u00ed como de la posibilidad de padecimiento de reacciones adversas (pseudoparkinsonismo). El consumo de tabaco determina el nivel plasm\u00e1tico de tioridazina y metabolitos. Podr\u00eda considerarse la posibilidad de que los pacientes fumadores se autoregulen los niveles plasm\u00e1ticos del antipsic\u00f3tico y de sus metabolitos, y por tanto los efectos farmacol\u00f3gicos (terap\u00e9uticos o adversos). La actividad del citocromo cyp2d6 y el consumo de tabaco determinan los niveles plasm\u00e1ticos de tioridazina y sus metabolitos mesoridazina y sulforidazina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacogenetica del metabolismo de tioridazina en pacientes psiquiatricos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacogenetica del metabolismo de tioridazina en pacientes psiquiatricos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rubia Martinez Alfredo De La <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Benitez Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Florez Beledo <\/li>\n<li>Mar\u00eda  Jes\u00fas Caballero Loscos (vocal)<\/li>\n<li>Rosario Calvo Duo (vocal)<\/li>\n<li>Jes\u00fas Cobaleda Polo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rubia Martinez Alfredo De La Tioridazina es un f\u00e1rmaco para el que se ha demostrado polimorfismo gen\u00e9tico. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,949,957,183,1408],"tags":[91599,9872,10701,19488,3586,91598],"class_list":["post-33648","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-extremadura","category-farmacologia","category-farmacos-psicotropicos","category-psiquiatria","tag-jesus-cobaleda-polo","tag-jesus-florez-beledo","tag-julio-benitez-rodriguez","tag-maria-jesus-caballero-loscos","tag-rosario-calvo-duo","tag-rubia-Martinez-alfredo-de-la"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=33648"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33648\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=33648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=33648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=33648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}