{"id":33664,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-enzima-3-hidroxi-3-metilglutaril-coa-sintasa-mitocondrial-como-marcador-de-lesion-del-sindrome-isquemia-reperfusion-en-el-trasplante-hepatico-experimental\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"la-enzima-3-hidroxi-3-metilglutaril-coa-sintasa-mitocondrial-como-marcador-de-lesion-del-sindrome-isquemia-reperfusion-en-el-trasplante-hepatico-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/la-enzima-3-hidroxi-3-metilglutaril-coa-sintasa-mitocondrial-como-marcador-de-lesion-del-sindrome-isquemia-reperfusion-en-el-trasplante-hepatico-experimental\/","title":{"rendered":"La enzima 3-hidroxi-3-metilglutaril coa sintasa mitocondrial como marcador de lesion del sindrome isquemia-reperfusion en el trasplante hepatico experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sergio Gonzalez Martinez <\/strong><\/h2>\n<p>La lesi\u00f3n por isquemia reperfusi\u00f3n inherente al proceso de trasplante hep\u00e1tico implica alteraciones a nivel de la perfusi\u00f3n del \u00f3rgano con variaciones metab\u00f3lica en forma de un aumento de la utilizaci\u00f3n de \u00e1cidos grasos como fuente de energia. Este hecho trae como consecuencia la existencia de variaciones en los niveles de cuerpos cet\u00f3nicos y del enzima hmg-coa sintasa mitocondrial que controla su s\u00edntesis en el h\u00edgado.  el presente estudio experimental en rata compara los niveles de cuerpos cet\u00f3nico, el cociente de cuerpos cet\u00f3nicos, el mrna y el enzima hmg-coa sintasa mitocondrial obtenidos en sangre arterial e h\u00edgado, tras realizar trasplante ortot\u00f3pico. Los h\u00edgados fueron sometidos a diferentes tiempos de preservaci\u00f3n (oh, 6h, 12h, 24h) en soluci\u00f3n de winsconsin.  los resultados muestran un aumento de la s\u00edntesis de cuerpos cet\u00f3nicos en el grupo de 6 horas de preservaci\u00f3n, que coincide con un descenso del cociente de cuerpos cet\u00f3nicos evidenciado una franca relaci\u00f3n inversa entre ambos valores. As\u00edmismo el cociente de cuerpos cet\u00f3nicos no muestra diferencias entre los valores de los grupos en la determinaci\u00f3n efectuada inmediatamente tras la reperfusi\u00f3n, coincidiendo con la literatura existente sobre el tema.  sin embargo los niveles de prote\u00edna tienen un aumento precoz tras la reperfusi\u00f3n del injerto, que es significativamente mayor en los grupos de 12 y 24 horas de preservaci\u00f3n que no tienen supervivencia a largo plazo por fallo hep\u00e1tico primario. Este hecho podr\u00eda ser de utilidad en la determinaci\u00f3n precoz de la viabilidad del injerto hep\u00e1tico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La enzima 3-hidroxi-3-metilglutaril coa sintasa mitocondrial como marcador de lesion del sindrome isquemia-reperfusion en el trasplante hepatico experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La enzima 3-hidroxi-3-metilglutaril coa sintasa mitocondrial como marcador de lesion del sindrome isquemia-reperfusion en el trasplante hepatico experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sergio Gonzalez Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>cruz P\u00e9rez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Eduard Jaurrieta Mas <\/li>\n<li>Carlos Margarit Creixell (vocal)<\/li>\n<li>Fausto Garcia Hegardt (vocal)<\/li>\n<li>Jos\u00e9 Bonnin Bonnin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sergio Gonzalez Martinez La lesi\u00f3n por isquemia reperfusi\u00f3n inherente al proceso de trasplante hep\u00e1tico implica alteraciones a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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