{"id":33683,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-al-estudio-de-la-cardiopatia-isquemica-y-su-relacion-con-la-concentracion-de-megx\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"contribucion-al-estudio-de-la-cardiopatia-isquemica-y-su-relacion-con-la-concentracion-de-megx","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/contribucion-al-estudio-de-la-cardiopatia-isquemica-y-su-relacion-con-la-concentracion-de-megx\/","title":{"rendered":"Contribucion al estudio de la cardiopatia isquemica y su relacion con la concentracion de megx."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jaime Lloret Rondon <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os asistimos a una progresi\u00f3n sustancial en la incidencia de cardiopat\u00eda isqu\u00e9mica. El infarto de miocardio, considerado como un proceso din\u00e1mico y no como una entidad est\u00e1tica, forma parte de los s\u00edndromes agudos coronarios, agrupados por una fisiopatolog\u00eda com\u00fan.  dichos s\u00edndromes son un \u00abcontinuum\u00bb que discurre por y desde la angina inestable hasta el infarto de miocardio transmural, pasando por el \u00abno q\u00bb y siempre con una v\u00eda abierta a la muerte s\u00fabita.  muchos pacientes con infarto agudo de miocardio presentan pruebas alteradas de la funci\u00f3n hep\u00e1tica, incluso en ausencia de insuficiencia cardiaca congestiva o de una hipotensi\u00f3n significativa, pero habitualmente no existen manifestaciones cl\u00ednicas de afectaci\u00f3n hep\u00e1tica.  el auge de los trasplantes a final de la d\u00e9cada de los 80 incita a desarrollar nuevos m\u00e9todos diagn\u00f3sticos y pron\u00f3sticos. Uno de ellos, la concentraci\u00f3n s\u00e9rica de monoetilglicinexilidida (megx) obtenida 15 minutos despu\u00e9s del bolo de lidoca\u00edna muestra tener una elevada sensibilidad y especificidad como indicador de disfunci\u00f3n hep\u00e1tica. Determinaciones seriadas de megx a tiempos mayores a los 15 minutos no han supuesto mayores ventajas.  la formaci\u00f3n de megx depende de la actividad del sistema enzim\u00e1tico hep\u00e1tico citocromo p-450, que cataliza una n- detilaci\u00f3n oxidativa de lidoca\u00edna. En estudios de microsomas hep\u00e1ticos humanos, el citocromo p-450 iii a4 ha sido identificado como uno de los enzimas involucrados en la formaci\u00f3n de megx.  el presente trabajo se realiz\u00f3 sobre pacientes en la fase aguda del infarto de miocardio, plante\u00e1ndonos los siguientes objetivos:  1. Poner de manifiesto la posible existencia de una alteraci\u00f3n de la funci\u00f3n hep\u00e1tica, cl\u00ednica o subcl\u00ednica, durante la fase aguda del infarto de miocardio, utilizando el megx-test 2. En el caso de demostrar la existencia de una afectaci\u00f3n de la funci\u00f3n hep\u00e1tica, valorar su posible<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribucion al estudio de la cardiopatia isquemica y su relacion con la concentracion de megx.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribucion al estudio de la cardiopatia isquemica y su relacion con la concentracion de megx. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jaime Lloret Rondon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alipio Mangas Rojas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Avelino Senra Varela <\/li>\n<li>Jos\u00e9 Mar\u00eda Esteban Carretero (vocal)<\/li>\n<li>Carlos Cardenal Sanchez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jaime Lloret Rondon En los \u00faltimos a\u00f1os asistimos a una progresi\u00f3n sustancial en la incidencia de cardiopat\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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