{"id":33689,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-fenotipica-y-funcional-de-los-linfocitos-infiltrantes-de-la-poliposis-nasosinusal\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"caracterizacion-fenotipica-y-funcional-de-los-linfocitos-infiltrantes-de-la-poliposis-nasosinusal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-fenotipica-y-funcional-de-los-linfocitos-infiltrantes-de-la-poliposis-nasosinusal\/","title":{"rendered":"Caracterizacion fenotipica y funcional de los linfocitos infiltrantes de la poliposis nasosinusal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Sanchez Segura <\/strong><\/h2>\n<p>La hip\u00f3tesis del trabajo fue que los linfocitos infiltrantes de la poliposis nasosinusal (pns) -una enfermedad inflamatoria cr\u00f3nica, recidivante y multifocal de la mucosa nasosinusal, cuyo origen es desconocido-, podr\u00edan estar implicados en la etiopatogenia de la enfermedad, y que el estudio de esta poblaci\u00f3n linfoide deber\u00eda permitir un acercamiento al mecanismo fisiopatol\u00f3gico que acontece en el seno de la pns.  para verificar la hip\u00f3tesis anterior se plantearon como objetivos, adem\u00e1s de realizar estudios histol\u00f3gicos sobre cuarenta casos de pns primarias, aislar la poblaci\u00f3n linfocitaria infiltrante en la pns. A continuaci\u00f3n, sobre esta poblaci\u00f3n linfocitaria aislada se realizar\u00edan estudios fenot\u00edpicos mediante citometr\u00eda de flujo y funcionales mediante pruebas in vitro.  estos estudios mostraron los siguientes resultados:  1. Los linfocitos t constituyen la poblaci\u00f3n linfoide mayoritaria infiltrante en la pns, siendo escasos los linfocitos b y las c\u00e9lulas nk.  2. Los linfocitos t de la pns son de memoria (cd45ro+); expresan una baja densidad de las mol\u00e9culas cd3, tcralfabeta y cd28; existe un ligero predominio de la poblaci\u00f3n cd8 sobre la cd4; aunque est\u00e1n en la fase g0\/1 del ciclo celular, presentan un estado de activaci\u00f3n especial (dr+\/cd69+) y muestran un perfil especializado de mol\u00e9culas de adhesi\u00f3n (cd103+\/cd54+\/cd62l- y cd49d de baja densidad).  3. Los linfocitos t de la pns proliferan poco tras su estimulaci\u00f3n in vitro; aunque expresan cd95, no hacen apoptosis espont\u00e1nea en cultivos ni tras su estimulaci\u00f3n con anti-cd95, y secretan un patr\u00f3n mixto th1\/th2 de citocinas, caracterizado por la producci\u00f3n espont\u00e1nea y simult\u00e1nea de ifn   e il-5. No producen il-4 y escasa il-2.  4. Las c\u00e9lulas plasm\u00e1ticas de la pns contienen en su mayor\u00eda iga intracitoplam\u00e1tica y se detectan muy pocas con ige intracitoplasm\u00e1tica. Las c\u00e9lulas plasm\u00e1ticas de la pns producen in vitro moderada cantidad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion fenotipica y funcional de los linfocitos infiltrantes de la poliposis nasosinusal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion fenotipica y funcional de los linfocitos infiltrantes de la poliposis nasosinusal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Sanchez Segura <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Brieva Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Bartual Pastor <\/li>\n<li>Carlos Suarez Nieto (vocal)<\/li>\n<li>Jos\u00e9 Pe\u00f1a Martinez (vocal)<\/li>\n<li>Jorge Roquete Gaona (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Sanchez Segura La hip\u00f3tesis del trabajo fue que los linfocitos infiltrantes de la poliposis nasosinusal (pns) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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