{"id":33697,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-de-2-aminoetilbenzociclanonas-como-potenciales-neurolepticos\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-farmacologico-de-2-aminoetilbenzociclanonas-como-potenciales-neurolepticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-de-2-aminoetilbenzociclanonas-como-potenciales-neurolepticos\/","title":{"rendered":"Estudio farmacologico de 2-aminoetilbenzociclanonas como potenciales neurolepticos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Alvarez Osuna <\/strong><\/h2>\n<p>La esquizofrenia, el trastorno psic\u00f3tico m\u00e1s com\u00fan, afecta al 1% de la poblaci\u00f3n mundial, con independencia de razas y culturas. Su incidencia se manifiesta por igual en hombres que en mujeres; no obstante, en el primer grupo los s\u00edntomas suelen aparecer entre los 15 y los 25 a\u00f1os, mientras que en el segundo la edad se retrasa hasta los 25 y 35 a\u00f1os.  la introducci\u00f3n de los neurol\u00e9pticos en cl\u00ednica a finales de la d\u00e9cada de los cincuenta, supuso una gran revoluci\u00f3n en el tratamiento de la esquizofrenia; por un lado, el empleo de estos f\u00e1rmacos produc\u00eda una mejora en el pron\u00f3stico de la enfermedad, y por otro lado, se produc\u00eda un cambio en la naturaleza de las instituciones mentales, pasando de ser meros centros de reclusi\u00f3n a centros m\u00e9dicos de control debido a una progresiva disminuci\u00f3n en la restricci\u00f3n de libertad de este tipo de pacientes.  la mayor\u00eda de estos f\u00e1rmacos, tambi\u00e9n denominados antipsic\u00f3ticos t\u00edpicos presenta dos grandes inconvenientes: (i) la inducci\u00f3n de s\u00edntomas extrapiramidales, y (ii) su ineficacia en el tratamiento de los s\u00edntomas negativos de la enfermedad.  en los a\u00f1os 70 se introdujeron en cl\u00ednica los antipsic\u00f3ticos at\u00edpicos, cuyo representante la clozapina, presenta una buena eficacia como antipsic\u00f3tico y solamente induce unos m\u00ednimos efectos extrapiramidales. A pesar de ello, esta dibenzodiacepina tuvo que ser retirada del mercado por los problemas de agranulocitosis que presenta.  ante la falta de alternativas terap\u00e9uticas se ha reintroducido en cl\u00ednica asociada inexcusablemente a un riguroso control hem\u00e1tico de los pacientes y \u00fanicamente en aquellos casos en los que la terapia con neurol\u00e9pticos resulta ineficaz.  esta falta de alternativas terap\u00e9uticas hace que este campo de la psicofarmacolog\u00eda se centre en la obtenci\u00f3n de nuevos compuestos que sean eficaces antipsic\u00f3ticos y que no induzcan los efectos indeseados comentados anteriormente.  a este resp<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacologico de 2-aminoetilbenzociclanonas como potenciales neurolepticos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacologico de 2-aminoetilbenzociclanonas como potenciales neurolepticos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Alvarez Osuna <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Calleja Suarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Isabel Cadavid Torres <\/li>\n<li>Antonio Zarzuelo (vocal)<\/li>\n<li>Enrique Ravi\u00f1a Rubira (vocal)<\/li>\n<li>Ferran Sanz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Alvarez Osuna La esquizofrenia, el trastorno psic\u00f3tico m\u00e1s com\u00fan, afecta al 1% de la poblaci\u00f3n mundial, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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