{"id":33743,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-inmunologica-y-fisiologica-de-la-proteina-de-union-del-hierro-fbpa-de-neisseria-meningitidis\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"caracterizacion-molecular-inmunologica-y-fisiologica-de-la-proteina-de-union-del-hierro-fbpa-de-neisseria-meningitidis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-molecular-inmunologica-y-fisiologica-de-la-proteina-de-union-del-hierro-fbpa-de-neisseria-meningitidis\/","title":{"rendered":"Caracterizacion molecular, inmunologica y fisiologica de la proteina de union del hierro, fbpa, de neisseria meningitidis."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gomez Diaz Jos\u00e9 Antonio <\/strong><\/h2>\n<p>En esta tesis doctoral se ha estudiado desde diferentes puntos de vista la prote\u00edna de neisseria meningitidis encargada del transporte del hierro al interior de la bacteria y que se denomina fbpa. Esta prote\u00edna ha sido identificada en todas las cepas meningoc\u00f3cicas, as\u00ed como en algunas especies comensales del g\u00e9nero neisseria, y se ha comprobado su car\u00e1cter de prote\u00edna regulada por el hierro, es decir, la fbpa se sintetiza en mayor cantidad cuando la bacteria crece en un ambiente con restricci\u00f3n del hierro.  se ha dise\u00f1ado un protocolo de purificaci\u00f3n de la prote\u00edna fbpa basado en la cromatograf\u00eda de afinidad a hierro que permite obtener la prote\u00edna en condiciones nativas. La determinaci\u00f3n del punto isoel\u00e9ctrico ha revelado un valor altamente b\u00e1sico, situado entre 9,2 y 9,5 y coincidente con el descrito para la fbpa de neisseria gonorrhoeae.  la disponibilidad de la prote\u00edna purificada en estado nativo ha permitido estudiar la respuesta inmune frente a la fbpa. Esta prote\u00edna es inmunog\u00e9nica en ratones y los anticuerpos dirigidos contra ella muestran una total reactividad cruzada cuando se enfrentaron con la prote\u00edna fbpa de diferentes cepas meningoc\u00f3cicas. Sin embargo, estos anticuerpos no poseen actividad bactericida significativa ni siquiera frente a la cepa hom\u00f3loga y no son capaces de bloquear la asimilaci\u00f3n del hierro a partir de diferentes fuentes del metal.  en ning\u00fan caso se han detectado anticuerpos anti-fbpa en sueros humanos procedentes de pacientes que hab\u00edan sido hospitalizados con infecci\u00f3n meningoc\u00f3cica de lo que se deduce la falta de inmunogenicidad in vivo de la prote\u00edna estudiada durante la infecci\u00f3n en el organismo humano.  en este trabajo se ha demostrado la exposici\u00f3n de la prote\u00edna fbpa en la superficie del meningococo. La demostraci\u00f3n se ha llevado a cabo por m\u00e9todos diversos como inmuno-ensayos en fase s\u00f3lida, en fase l\u00edquida y, sobre todo, utilizando la inmunomicrosco<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion molecular, inmunologica y fisiologica de la proteina de union del hierro, fbpa, de neisseria meningitidis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion molecular, inmunologica y fisiologica de la proteina de union del hierro, fbpa, de neisseria meningitidis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gomez Diaz Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Mar\u00eda Ferreir\u00f3s  Dom\u00ednguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge Blanco \u00e1lvarez <\/li>\n<li>Sonsoles Berron Morato (vocal)<\/li>\n<li>Julio A. V\u00e1zquez Moreno (vocal)<\/li>\n<li>Luis Sanchez Lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gomez Diaz Jos\u00e9 Antonio En esta tesis doctoral se ha estudiado desde diferentes puntos de vista la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1418,35,1737,278,977,2714],"tags":[2981,91784,34805,21267,2550,91785],"class_list":["post-33743","post","type-post","status-publish","format-standard","hentry","category-bacteriologia","category-ciencias-de-la-vida","category-inmunologia","category-microbiologia","category-santiago-de-compostela","category-vacunas","tag-carlos-maria-ferreiros-dominguez","tag-gomez-diaz-jose-antonio","tag-jorge-blanco-alvarez","tag-julio-a-vazquez-moreno","tag-luis-sanchez-lopez","tag-sonsoles-berron-morato"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33743","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=33743"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33743\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=33743"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=33743"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=33743"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}